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J Appl Physiol 92: 1594-1602, 2002; doi:10.1152/japplphysiol.00722.2001
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Vol. 92, Issue 4, 1594-1602, April 2002

Role of capacitative Ca2+ entry in bronchial contraction and remodeling

Michele Sweeney1,*, Sharon S. McDaniel1,*, Oleksandr Platoshyn1,*, Shen Zhang1, Ying Yu1, Bethany R. Lapp1, Ying Zhao1, Patricia A. Thistlethwaite2, and Jason X.-J. Yuan1

1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, and 2 Division of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of California, San Diego, California 92103

Asthma is characterized by airway inflammation, bronchial hyperresponsiveness, and airway obstruction by bronchospasm and bronchial wall thickening due to smooth muscle hypertrophy. A rise in cytosolic free Ca2+ concentration ([Ca2+]cyt) may serve as a shared signal transduction element that causes bronchial constriction and bronchial wall thickening in asthma. In this study, we examined whether capacitative Ca2+ entry (CCE) induced by depletion of intracellular Ca2+ stores was involved in agonist-mediated bronchial constriction and bronchial smooth muscle cell (BSMC) proliferation. In isolated bronchial rings, acetylcholine (ACh) induced a transient contraction in the absence of extracellular Ca2+ because of Ca2+ release from intracellular Ca2+ stores. Restoration of extracellular Ca2+ in the presence of atropine, an M-receptor blocker, induced a further contraction that was apparently caused by a rise in [Ca2+]cyt due to CCE. In single BSMC, amplitudes of the store depletion-activated currents (ISOC) and CCE were both enhanced when the cells proliferate, whereas chelation of extracellular Ca2+ with EGTA significantly inhibited the cell growth in the presence of serum. Furthermore, the mRNA expression of TRPC1, a transient receptor potential channel gene, was much greater in proliferating BSMC than in growth-arrested cells. Blockade of the store-operated Ca2+ channels by Ni2+ decreased ISOC and CCE and markedly attenuated BSMC proliferation. These results suggest that upregulated TRPC1 expression, increased ISOC, enhanced CCE, and elevated [Ca2+]cyt may play important roles in mediating bronchial constriction and BSMC proliferation.

asthma; transient receptor potential gene; store-operated cation channels

*  M. Sweeney, S.S. McDaniel, and O. Platoshyn contributed equally to the work.




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