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Most of the references in the expanded bibliography (available with the electronic version of the paper) were found through an internet search (http://pubmed.gov/entrez/query.fcgi) . The following MeSH terms are compatible with format for the search engine and can be copied into the search box: (rats OR mice) AND (simulat* weightless* OR hindlimb* unload* OR hindlimb suspen* OR hindquarter* unload* OR tail suspen* OR altered gravity). Articles from this search will not be solely those that use the NASA rat model, but will also include other unloading or altered gravity paradigms such as spaceflight, centrifugation, miscellaneous cell cultures, and other animal unloading models. We have accumulated a list of 814 references relevant specifically to the hindlimb unloading model, 193 of which were published in J. Appl. Physiol. This reference list is available on the J. Appl. Physiol. website with the electronic version of this paper.
REFERENCES
1.Aboudrar S, Desplanches D, Graber-von Bergen F, Favier R, Okyayuz-Baklouti I, and Hoppeler H. Effects of torbafylline on muscle atrophy: prevention and recovery. Can J Physiol Pharmacol 70: 814-820, 1992.
2.Aboudrar S, Sempore B, Koubi H, Dechaud H, and Desplanches D. Effects of adrenalectomy or RU-486 on rat muscle fibers during hindlimb suspension. J Appl Physiol 75: 2767-2773, 1993.
3.Abram AC, Keller TS, and Spengler DM. The effects of simulated weightlessness on bone biomechanical and biochemical properties in the maturing rat. J Biomech 21: 755-767, 1988.
4.Adams GR, Haddad F, and Baldwin KM. Interaction of chronic creatine depletion and muscle unloading: effects on postural locomotor muscles. J Appl Physiol 77: 1198-1205, 1994.
5.Alekseev EI, Loginov VI, and Kaplanskii AS. [Effects of support++ loads and stimulation of CNS on functional activity of somatotrops and thyreocytes in suspended rats]. Aviakosm Ekolog Med 32: 28-31, 1998.
6.Alford EK, Roy RR, Hodgson JA, and Edgerton VR. Electromyography of rat soleus, medial gastrocnemius, and tibialis anterior during hind limb suspension. Exp Neurol 96: 635-649, 1987.
7.Allaf O, and Goubel F. The rat suspension model is also a good tool for inducing muscle hyperactivity. Pflugers Arch 437: 504-507, 1999.
8.Allen DL, Linderman JK, Roy RR, Bigbee AJ, Grindeland RE, Mukku V, and Edgerton VR. Apoptosis: a mechanism contributing to remodeling of skeletal muscle in response to hindlimb unweighting. Am J Physiol 273: C579-587, 1997.
9.Allen DL, Linderman JK, Roy RR, Grindeland RE, Mukku V, and Edgerton VR. Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles. J Appl Physiol 83: 1857-1861, 1997.
10.Alley KA, and Thompson LV. Influence of simulated bed rest and intermittent weight bearing on single skeletal muscle fiber function in aged rats. Arch Phys Med Rehabil 78: 19-25, 1997.
11.Almeida-Silveira MI, Lambertz D, Perot C, and Goubel F. Changes in stiffness induced by hindlimb suspension in rat Achilles tendon. Eur J Appl Physiol 81: 252-257, 2000.
12.Alway S, Lowe D, and Chen D. The effects of age and hindlimb supension on the levels of expression of the myogenic regulatory factors MyoD and myogenin in rat fast and slow skeletal muscles. Exp Physiol 86: 509-517, 2001.
13.Amann RP, Deaver DR, Zirkin BR, Grills GS, Sapp WJ, Veeramachaneni DN, Clemens JW, Banerjee SD, Folmer J, Gruppi CM, Wolgemuth DJ, and Williams CS. Effects of microgravity or simulated launch on testicular function in rats. J Appl Physiol 73: 174S-185S, 1992.
14.Anderson J, Almeida-Silveira MI, and Perot C. Reflex and muscular adaptations in rat soleus muscle after hindlimb suspension. J Exp Biol 202: 2701-2707, 1999.
15.Apseloff G, Girten B, Gerber N, Shepard DR, and Matkovic V. Lack of effect of gallium nitrate on bone density in a rat model of simulated microgravity. Aviat Space Environ Med 63: 27-31, 1992.
16.Apseloff G, Girten B, Walker M, Shepard DR, Krecic ME, Stern LS, and Gerber N. Aminohydroxybutane bisphosphonate and clenbuterol prevent bone changes and retard muscle atrophy respectively in tail-suspended rats. J Pharmacol Exp Ther 264: 1071-1078, 1993.
17.Apseloff G, Girten B, Weisbrode SE, Walker M, Stern LS, Krecic ME, and Gerber N. Effects of aminohydroxybutane bisphosphonate on bone growth when administered after hind-limb bone loss in tail-suspended rats. J Pharmacol Exp Ther 267: 515-521, 1993.
18.Arkhipenko IV, Popova IA, Stepanova VV, Sazontova TG, and Meerson FZ. [Ca2+ transport by the skeletal muscle sarcoplasmic reticulum in rats after suspension of the hindlimbs]. Biull Eksp Biol Med 116: 253-256, 1993.
19.Armstrong JW, Balch S, and Chapes SK. Interleukin-2 therapy reverses some immunosuppressive effects of skeletal unloading. J Appl Physiol 77: 584-589, 1994.
20.Armstrong JW, Kirby-Dobbels K, and Chapes SK. The effects of rM-CSF and rIL-6 therapy on immunosuppressed antiorthostatically suspended mice. J Appl Physiol 78: 968-975, 1995.
21.Armstrong JW, Nelson KA, Simske SJ, Luttges MW, Iandolo JJ, and Chapes SK. Skeletal unloading causes organ-specific changes in immune cell responses. J Appl Physiol 75: 2734-2739, 1993.
22.Arnaud SB, Fung P, Popova IA, Morey-Holton ER, and Grindeland RE. Circulating parathyroid hormone and calcitonin in rats after spaceflight. J Appl Physiol 73: 169S-173S, 1992.
23.Arnaud SB, Harper JS, and Navidi M. Mineral distribution in rat skeletons after exposure to a microgravity model. J Gravit Physiol 2: 115-116, 1995.
24.Asmussen G, Miersch H, and Soukup T. The influence of suspension hypokinesia on contractile properties of slow and fast twitch muscles of young growing and adult rats. Biomed Biochim Acta 48: S426-431, 1989.
25.Asmussen G, and Soukup T. Arrest of developmental conversion of type II to type I fibres after suspension hypokinesia. Histochem J 23: 312-322, 1991.
26.Assenmacher I, Mekaouche M, Maurel D, Barbanel G, Givalois L, Boissin J, Malaval F, and Ixart G. Chronic orthostatic and antiorthostatic restraint induce neuroendocrine, immune and neurophysiologial disorders in rats. Acta Astronaut 36: 545-558, 1995.
27.Atomi Y, Yamada S, and Nishida T. Early changes of alpha B-crystallin mRNA in rat skeletal muscle to mechanical tension and denervation. Biochem Biophys Res Commun 181: 1323-1330, 1991.
28.Atomi Y, Yamada S, Strohman R, and Nonomura Y. Alpha B-crystallin in skeletal muscle: purification and localization. J Biochem (Tokyo) 110: 812-822, 1991.
29.Attaix D, Taillandier D, Combaret L, Ralliere C, Larbaud D, Aurousseau E, and Tanaka K. Expression of subunits of the 19S complex and of the PA28 activator in rat skeletal muscle. Mol Biol Rep 24: 95-98, 1997.
30.Awede B, Thissen J, Gailly P, and Lebacq J. Regulation of IGF-I, IGFBP-4 and IGFBP-5 gene expression by loading in mouse skeletal muscle. FEBS Lett 461: 263-267, 1999.
31.Babij P, and Booth FW. Alpha-actin and cytochrome c mRNAs in atrophied adult rat skeletal muscle. Am J Physiol 254: C651-656, 1988.
32.Babij P, and Booth FW. Clenbuterol prevents or inhibits loss of specific mRNAs in atrophying rat skeletal muscle. Am J Physiol 254: C657-660, 1988.
33.Bai S, Xie L, Liu C, Zheng Q, and Chen J. [Effects of octacosanol in food physiological parameters in tail-suspended rats]. Space Med Med Eng (Beijing) 10: 450-452, 1997.
34.Baldwin KM. Effects of altered loading states on muscle plasticity: what have we learned from rodents? Med Sci Sports Exerc 28: S101-106, 1996.
35.Baldwin KM, and Haddad F. Effects of different activity and inactivity paradigms on myosin heavy chain gene expression in striated muscle. J Appl Physiol 90: 345-357, 2001.
36.Baldwin KM, Herrick RE, and McCue SA. Substrate oxidation capacity in rodent skeletal muscle: effects of exposure to zero gravity. J Appl Physiol 75: 2466-2470, 1993.
37.Bangart JJ, Widrick JJ, and Fitts RH. Effect of intermittent weight bearing on soleus fiber force-velocity-power and force-pCa relationships. J Appl Physiol 82: 1905-1910, 1997.
38.Barou O, Lafage-Proust MH, Martel C, Thomas T, Tirode F, Laroche N, Barbier A, Alexandre C, and Vico L. Bisphosphonate effects in rat unloaded hindlimb bone loss model: three-dimensional microcomputed tomographic, histomorphometric, and densitometric analyses. J Pharmacol Exp Ther 291: 321-328, 1999.
39.Barou O, Palle S, Vico L, Alexandre C, and Lafage-Proust MH. Hindlimb unloading in rat decreases preosteoblast proliferation assessed in vivo with BrdU incorporation. Am J Physiol 274: E108-114, 1998.
40.Bastide B, Conti A, Sorrentino V, and Mounier Y. Properties of ryanodine receptor in rat muscles submitted to unloaded conditions. Biochem Biophys Res Commun 270: 442-447, 2000.
41.Bateman TA, Broz JJ, Fleet ML, and Simske SJ. Differing effects of two-week suspension on male and female mouse bone metabolism. Biomed Sci Instrum 34: 374-379, 1997.
42.Bateman TA, Dunstan CR, Ferguson VL, Lacey DL, Ayers RA, and Simske SJ. Osteoprotegerin mitigates tail suspension-induced osteopenia. Bone 26: 443-449, 2000.
43.Bayorh MA, Socci RR, Watts S, Wang M, Eatman D, Emmett N, and Thierry-Palmer M. L-name, a nitric oxide synthase inhibitor, as a potential countermeasure to post-suspension hypotension in rats. Clin Exp Hypertens 23: 611-622, 2001.
44.Bayorh MA, Wang M, Socci RR, Eatman D, Emmett N, and Thierry-Palmer M. Angiotensin-(1-7) antagonist [D-Ala7-Ang-(1-7);A-779] attenuates post-suspension hypotension in Sprague-Dawley rats. J Gravit Physiol 6: 115-116, 1999.
45.Bayoroh MA, Socci RR, Wang M, Thierry-Palmer M, and Emmett N. Influence of simulated microgravity on cardiovascular and hemodynamic parameters in Dahl salt-sensitive rats. J Gravit Physiol 6: 63-70, 1999.
46.Belakovskii MS, and Khaidakov MS. [Effect of active metabolites of vitamin D 3 on the status of rat bone tissue in various experimental models of hypokinesia]. Kosm Biol Aviakosm Med 23: 36-39, 1989.
47.Bell GJ, Martin TP, Ilyina-Kakueva EI, Oganov VS, and Edgerton VR. Altered distribution of mitochondria in rat soleus muscle fibers after spaceflight. J Appl Physiol 73: 493-497, 1992.
48.Berezovs'kyi VI, Litovka IH, and Chaka OH. [The effect of measured hypoxia on the development of situational osteopenia]. Fiziol Zh 46: 10-16, 2000.
49.Bergula AP, Huang W, and Frangos JA. Femoral vein ligation increases bone mass in the hindlimb suspended rat. Bone 24: 171-177, 1999.
50.Berry WD, Murphy JD, Smith BA, Taylor GR, and Sonnenfeld G. Effect of microgravity modeling on interferon and interleukin responses in the rat. J Interferon Res 11: 243-249, 1991.
51.Bigard AX, Boehm E, Veksler V, Mateo P, Anflous K, and Ventura-Clapier R. Muscle unloading induces slow to fast transitions in myofibrillar but not mitochondrial properties. Relevance to skeletal muscle abnormalities in heart failure. J Mol Cell Cardiol 30: 2391-2401, 1998.
52.Bigard AX, Lienhard F, Merino D, Serrurier B, and Guezennec CY. Effects of growth hormone on rat skeletal muscle after hindlimb suspension. Eur J Appl Physiol Occup Physiol 69: 337-343, 1994.
53.Bigard AX, Merino D, Lienhard F, Serrurier B, and Guezennec CY. Muscle damage induced by running training during recovery from hindlimb suspension: the effect of dantrolene sodium. Eur J Appl Physiol Occup Physiol 76: 421-427, 1997.
54.Bigard AX, Merino D, Lienhard F, Serrurier B, and Guezennec CY. Quantitative assessment of degenerative changes in soleus muscle after hindlimb suspension and recovery. Eur J Appl Physiol Occup Physiol 75: 380-387, 1997.
55.Bigard AX, Serrurier B, Merino D, Lienhard F, Berthelot M, and Guezennec CY. Myosin heavy chain composition of regenerated soleus muscles during hindlimb suspension. Acta Physiol Scand 161: 23-30, 1997.
56.Bigard AX, Serrurier B, Merino D, Lienhard F, and Guezennec CY. Structural and biochemical properties of the rat myocardium after 21 days of head-down suspension. Aviat Space Environ Med 65: 829-834, 1994.
57.Bigard XA, Merino D, Serrurier B, Lienhard F, Guezennec YC, Bockhold KJ, and Whalen RG. Role of weight-bearing function on expression of myosin isoforms during regeneration of rat soleus muscles. Am J Physiol 270: C763-771, 1996.
58.Bikle DD, Globus RK, and Morey ER. Calcium transport from the intestine and into bone in a rat model simulating weightlessness. Physiologist 25: S143-144, 1982.
59.Bikle DD, and Halloran BP. The response of bone to unloading. J Bone Miner Metab 17: 233-244, 1999.
60.Bikle DD, Halloran BP, Cone CM, Globus RK, and Morey-Holton E. The effects of simulated weightlessness on bone maturation. Endocrinology 120: 678-684, 1987.
61.Bikle DD, Halloran BP, Cone CM, and Morey-Holton E. Bone loss during simulated weightlessness: is it glucocorticoid mediated? Physiologist 28: S123-124, 1985.
62.Bikle DD, Halloran BP, and Morey-Holton E. Impact of skeletal unloading on bone formation: role of systemic and local factors. Acta Astronaut 33: 119-129, 1994.
63.Bikle DD, Halloran BP, and Morey-Holton E. Space flight and the skeleton: lessons for the earthbound. Endocrinologist 7: 10-22, 1997.
64.Bikle DD, Halloran BP, and Morey-Holton E. Spaceflight and the skeleton: lessons for the earthbound. Gravit Space Biol Bull 10: 119-135, 1997.
65.Bikle DD, Harris J, Halloran BP, Currier PA, Tanner S, and Morey-Holton E. The molecular response of bone to growth hormone during skeletal unloading: regional differences. Endocrinology 136: 2099-2109, 1995.
66.Bikle DD, Harris J, Halloran BP, and Morey-Holton E. Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation. Am J Physiol 267: E822-827, 1994.
67.Bikle DD, Harris J, Halloran BP, and Morey-Holton ER. Skeletal unloading induces resistance to insulin-like growth factor I. J Bone Miner Res 9: 1789-1796, 1994.
68.Bikle DD, Morey-Holton ER, Doty SB, Currier PA, Tanner SJ, and Halloran BP. Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage. J Bone Miner Res 9: 1777-1787, 1994.
69.Biondi R, Capodicasa E, Tassi C, Mezzasoma L, Benedetti C, Valiani M, Marconi P, and Rossi R. Cardiovascular and organ responses and adaptation responses to hypogravity in an experimental animal model. Acta Astronaut 37: 373-377, 1995.
70.Blanc S, Geloen A, Pachiaudi C, Gharib C, and Normand S. Validation of the doubly labeled water method in rats during isolation and simulated weightlessness. Am J Physiol Regul Integr Comp Physiol 279: R1964-1979, 2000.
71.Blewett C, and Elder GC. Quantitative EMG analysis in soleus and plantaris during hindlimb suspension and recovery. J Appl Physiol 74: 2057-2066, 1993.
72.Bloomfield S, Girten B, Weisbrode S, Eveland E, and Kazarian L. Modifications of bone atrophy seen with hindlimb suspension by exercise and dobutamine. Physiologist 32: S27-28, 1989.
73.Bloomfield SA, Girten BE, and Weisbrode SE. Effects of vigorous exercise training and beta-agonist administration on bone response to hindlimb suspension. J Appl Physiol 83: 172-178, 1997.
74.Bonen A, Blewett C, McDermott JC, and Elder GC. A model for nonexercising hindlimb muscles in exercising animals. Can J Physiol Pharmacol 68: 914-921, 1990.
75.Bonen A, Elder GC, and Tan MH. Hindlimb suspension increases insulin binding and glucose metabolism. J Appl Physiol 65: 1833-1839, 1988.
76.Booth FW. Physiologic and biochemical effects of immobilization on muscle. Clin Orthop: 15-20, 1987.
77.Booth FW, and Gollnick PD. Effects of disuse on the structure and function of skeletal muscle. Med Sci Sports Exerc 15: 415-420, 1983.
78.Booth FW, and Grindeland RE. Comparison of the physiology of the spaceflight and hindlimb suspended rat. In: Final Reports of the U. S. experiments flown on the Soviet Biosatellite Cosmos 2044, NASA TM 108802, edited by J. P. Connolly, R. E. Grindeland and R. W. Ballard. Moffett Field: NASA Ames Research Center, 1994, p. 275-281.
79.Booth FW, and Kirby CR. Changes in skeletal muscle gene expression consequent to altered weight bearing. Am J Physiol 262: R329-332, 1992.
80.Booth FW, and Thomason DB. Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models. Physiol Rev 71: 541-585, 1991.
81.Bourrin S, Palle S, Genty C, and Alexandre C. Physical exercise during remobilization restores a normal bone trabecular network after tail suspension-induced osteopenia in young rats. J Bone Miner Res 10: 820-828, 1995.
82.Bouzeghrane F, Fagette S, Somody L, Allevard AM, Gharib C, and Gauquelin G. Restraint vs. hindlimb suspension on fluid and electrolyte balance in rats. J Appl Physiol 80: 1993-2001, 1996.
83.Bouzeghrane F, Somody L, Gallo-Bona N, Gauquelin-Koch G, Gharib C, and Fagette S. Effect of a 14-day hindlimb suspension on beta-adrenoreceptors in rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 123: 95-102, 1999.
84.Bricout VA, Serrurier BD, Bigard AX, and Guezennec CY. Effects of hindlimb suspension and androgen treatment on testosterone receptors in rat skeletal muscles. Eur J Appl Physiol Occup Physiol 79: 443-448, 1999.
85.Brizzee BL, and Walker BR. Altered baroreflex function after tail suspension in the conscious rat. J Appl Physiol 69: 2091-2096, 1990.
86.Brown M, Fisher JS, and Hasser EM. Gonadectomy and reduced physical activity: effects on skeletal muscle. Archives of Physical Medicine and Rehabilitation 82: 93-97, 2001.
87.Brown M, Fisher JS, and Salsich G. Stiffness and muscle function with age and reduced muscle use. J Orthop Res 17: 409-414, 1999.
88.Brown M, and Hasser EM. Differential effects of reduced muscle use (hindlimb unweighting) on skeletal muscle with aging. Aging (Milano) 8: 99-105, 1996.
89.Brown M, and Hasser EM. Weight-bearing effects on skeletal muscle during and after simulated bed rest. Arch Phys Med Rehabil 76: 541-546, 1995.
90.Brunner LJ, Bai S, and Abdus-Salaam H. Effect of simulated weightlessness on phase II drug metabolism in the rat. Aviat Space Environ Med 71: 899-903, 2000.
91.Brunner LJ, DiPiro JT, and Feldman S. Antipyrine pharmacokinetics in the tail-suspended rat model. J Pharmacol Exp Ther 274: 345-352, 1995.
92.Bulekbaeva LE, Demchenko GA, and Khanturin MR. [The contractile activity of the lymphatic vessels in rats after head-down tilt exposure]. Fiziol Zh Im I M Sechenova 80: 77-80, 1994.
93.Bychkova EI, Krotov VP, Moleva EB, and Medvedev OS. [The dynamics of the central and peripheral blood circulation in waking rats in the first 24 hours of head-down tilt hypokinesia (the role of training)]. Aviakosm Ekolog Med 26: 60-64, 1992.
94.Bychkova EI, Martynova ER, Medvedev OS, Krotov VP, and Meertsuk FE. [Systemic and regional hemodynamics in conscious rats during 24-hour antiorthostatic posture]. Biull Eksp Biol Med 109: 20-23, 1990.
95.Bychkova EI, Matsievskii DD, and Krotov VP. [Effect of training to antiorthostatic hypokinesia on parameters of the central hemodynamics in rats]. Biull Eksp Biol Med 126: 289-293, 1998.
96.Bytchkova EY, Medvedev OS, Matsievsky DD, and Krotov VP. Effects of hindlimb suspension training on the central and regional hemodynamic responses during 24 hours antiorthostatic hypokinesia in the awake rat. J Gravit Physiol 1: 137-138, 1994.
97.Caiozzo VJ, Baker MJ, and Baldwin KM. Novel transitions in MHC isoforms: separate and combined effects of thyroid hormone and mechanical unloading. J Appl Physiol 85: 2237-2248, 1998.
98.Caiozzo VJ, Baker MJ, McCue SA, and Baldwin KM. Single-fiber and whole muscle analyses of MHC isoform plasticity: interaction between T3 and unloading. Am J Physiol 273: C944-952, 1997.
99.Campione M, Ausoni S, Guezennec CY, and Schiaffino S. Myosin and troponin changes in rat soleus muscle after hindlimb suspension. J Appl Physiol 74: 1156-1160, 1993.
100.Canon F, and Goubel F. Changes in stiffness induced by hindlimb suspension in rat soleus muscle. Pflugers Arch 429: 332-337, 1995.
101.Canon F, Goubel F, and Guezennec CY. Effects of chronic low frequency stimulation on contractile and elastic properties of hindlimb suspended rat soleus muscle. Eur J Appl Physiol Occup Physiol 77: 118-124, 1998.
102.Canton F, Bigard AX, Merino D, Lienhard F, and Guezennec CY. Effects of chronic low frequency stimulation on structural and metabolic properties of hindlimb suspended rat soleus muscle. Eur J Appl Physiol Occup Physiol 70: 528-535, 1995.
103.Canu M, Stevens L, Ricart-Firinga C, Picquet F, and Falempin M. Effect of the beta(2)-agonist clenbuterol on the locomotor activity of rat submitted to a 14-day period of hypodynamia-hypokinesia. Behav Brain Res 122: 103-112, 2001.
104.Canu MH, and Falempin M. Effect of hindlimb unloading on interlimb coordination during treadmill locomotion in the rat. Eur J Appl Physiol Occup Physiol 78: 509-515, 1998.
105.Canu MH, and Falempin M. Effect of hindlimb unloading on locomotor strategy during treadmill locomotion in the rat. Eur J Appl Physiol Occup Physiol 74: 297-304, 1996.
106.Canu MH, and Falempin M. Effect of hindlimb unloading on two hindlimb muscles during treadmill locomotion in rats. Eur J Appl Physiol Occup Physiol 75: 283-288, 1997.
107.Canu MH, Falempin M, and Orsal D. Fictive motor activity in rat after 14 days of hindlimb unloading. Exp Brain Res 139: 30-38, 2001.
108.Capodicasa E, Tassi C, Rossi R, Mezzasoma L, Valiani M, and Biondi R. Effect of antiorthostatic hypokinetic/hypodynamia on urinary endothelin-1 and N-acetyl-beta-D-glucosaminidase excretion in rats. Clin Chim Acta 260: 35-48, 1997.
109.Carcenac C, Herbute S, Masseguin C, Mani-Ponset L, Maurel D, Briggs R, Guell A, and Gabrion JB. Hindlimb-suspension and spaceflight both alter cGMP levels in rat choroid plexus. J Gravit Physiol 6: 17-24, 1999.
110.Caren LD, Mandel AD, and Nunes JA. Effect of simulated weightlessness on the immune system in rats. Aviat Space Environ Med 51: 251-255, 1980.
111.Carlson CJ, Booth FW, and Gordon SE. Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading. Am J Physiol 277: R601-606, 1999.
112.Cartee GD. What insights into age-related changes in skeletal muscle are provided by animal models? J Gerontol A Biol Sci Med Sci 50: 137-141, 1995.
113.Chapes SK, Mastro AM, Sonnenfeld G, and Berry WD. Antiorthostatic suspension as a model for the effects of spaceflight on the immune system. J Leukoc Biol 54: 227-235, 1993.
114.Chen J, Zhang LF, Han C, Yu GS, and Ma J. Modulation of myocardial alpha 1- but not beta-adrenoceptors after 90-day tail-suspension. J Gravit Physiol 3: 57-62, 1996.
115.Chen KD, and Alway SE. Clenbuterol reduces soleus muscle fatigue during disuse in aged rats. Muscle Nerve 24: 211-222, 2001.
116.Chen KD, and Alway SE. A physiological level of clenbuterol does not prevent atrophy or loss of force in skeletal muscle of old rats. J Appl Physiol 89: 606-612, 2000.
117.Chew HG, Jr, and Segal SS. Arterial morphology and blood volumes of rats following 10-14 weeks of tail suspension. Med Sci Sports Exerc 29: 1304-1310, 1997.
118.Chi MM, Choksi R, Nemeth P, Krasnov I, Ilyina-Kakueva E, Manchester JK, and Lowry OH. Effects of microgravity and tail suspension on enzymes of individual soleus and tibialis anterior fibers. J Appl Physiol 73: 66S-73S, 1992.
119.Chopard A, Pons F, and Marini JF. Cytoskeletal protein contents before and after hindlimb suspension in a fast and slow rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol 280: R323-330, 2001.
120.Chowdhury P, Soulsby ME, and Pasley JN. Distribution of 3H-nicotine in rat tissues under the influence of simulated microgravity. Biomed Environ Sci 12: 103-109, 1999.
121.Colleran PN, Wilkerson MK, Bloomfield SA, Suva LJ, Turner RT, and Delp MD. Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling. J Appl Physiol 89: 1046-1054, 2000.
122.Corley K, Kowalchuk N, and McComas AJ. Contrasting effects of suspension on hind limb muscles in the hamster. Exp Neurol 85: 30-40, 1984.
123.Criswell DS, Booth FW, DeMayo F, Schwartz RJ, Gordon SE, and Fiorotto ML. Overexpression of IGF-I in skeletal muscle of transgenic mice does not prevent unloading-induced atrophy. Am J Physiol 275: E373-379, 1998.
124.Criswell DS, Carson JA, and Booth FW. Regulation of contractile protein gene expression in unloaded mouse skeletal muscle. J Gravit Physiol 3: 58-60, 1996.
125.Criswell DS, Hodgson VR, Hardeman EC, and Booth FW. Nerve-responsive troponin I slow promoter does not respond to unloading. J Appl Physiol 84: 1083-1087, 1998.
126.Cros N, Muller J, Bouju S, Pietu G, Jacquet C, Leger JJ, Marini JF, and Dechesne CA. Upregulation of M-creatine kinase and glyceraldehyde3-phosphate dehydrogenase: two markers of muscle disuse. Am J Physiol 276: R308-316, 1999.
127.Cui W, Shi Z, Fu H, Zheng Q, and Qiu L. [Comparison of changes of bone mass, parathyroid hormone and calcitonin between two animal models of bone loss]. Zhongguo Ying Yong Sheng Li Xue Za Zhi 13: 5-8, 1997.
128.Cui W, Shi Z, Liu C, and Zheng Q. Changes in bone noncollagenous proteins and bone mineral loss in lumbar vertebrae of tail-suspended rats. Space Med Med Eng (Beijing) 10: 401-404, 1997.
129.D'Amelio F, Fox RA, Wu LC, and Daunton NG. Quantitative changes of GABA-immunoreactive cells in the hindlimb representation of the rat somatosensory cortex after 14-day hindlimb unloading by tail suspension. J Neurosci Res 44: 532-539, 1996.
130.D'Aunno DS, Robinson RR, Smith GS, Thomason DB, and Booth FW. Intermittent acceleration as a countermeasure to soleus muscle atrophy. J Appl Physiol 72: 428-433, 1992.
131.D'Aunno DS, Thomason DB, and Booth FW. Centrifugal intensity and duration as countermeasures to soleus muscle atrophy. J Appl Physiol 69: 1387-1389, 1990.
132.Darr KC, and Schultz E. Hindlimb suspension suppresses muscle growth and satellite cell proliferation. J Appl Physiol 67: 1827-1834, 1989.
133.Davet J, Clavel B, Datas L, Mani-Ponset L, Maurel D, Herbute S, Viso M, Hinds W, Jarvi J, and Gabrion J. Choroidal readaptation to gravity in rats after spaceflight and head-down tilt. J Appl Physiol 84: 19-29, 1998.
134.Davydova NA, Shishkina SK, Korneeva NV, Suprunova EV, and Ushakov AS. [Biochemical aspects of the functioning of neurohumoral systems in long-term head-down tilt hypokinesia]. Kosm Biol Aviakosm Med 20: 91-95, 1986.
135.De-Doncker L, Picquet F, and Falempin M. Effects of cutaneous receptor stimulation on muscular atrophy developed in hindlimb unloading condition. J Appl Physiol 89: 2344-2351, 2000.
136.Deaver DR, Amann RP, Hammerstedt RH, Ball R, Veeramachaneni DN, and Musacchia XJ. Effects of caudal elevation on testicular function in rats. Separation of effects on spermatogenesis and steroidogenesis. J Androl 13: 224-231, 1992.
137.Deavers DR, Musacchia XJ, and Meininger GA. Model for antiorthostatic hypokinesia: head-down tilt effects on water and salt excretion. J Appl Physiol 49: 576-582, 1980.
138.Dehority W, Halloran BP, Bikle DD, Curren T, Kostenuik PJ, Wronski TJ, Shen Y, Rabkin B, Bouraoui A, and Morey-Holton E. Bone and hormonal changes induced by skeletal unloading in the mature male rat. Am J Physiol 276: E62-69, 1999.
139.Delp MD. Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloading. J Appl Physiol 86: 1178-1184, 1999.
140.Delp MD, Brown M, Laughlin MH, and Hasser EM. Rat aortic vasoreactivity is altered by old age and hindlimb unloading. J Appl Physiol 78: 2079-2086, 1995.
141.Delp MD, Colleran PN, Wilkerson MK, McCurdy MR, and Muller-Delp J. Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravity. Am J Physiol Heart Circ Physiol 278: H1866-1873, 2000.
142.Delp MD, Holder-Binkley T, Laughlin MH, and Hasser EM. Vasoconstrictor properties of rat aorta are diminished by hindlimb unweighting. J Appl Physiol 75: 2620-2628, 1993.
143.Denjean F, Desplanches D, Lachuer J, Cohen-Adad F, Mayet MH, and Duchamp C. Muscle-specific up-regulation of rat UCP3 mRNA expression by long-term hindlimb unloading. Biochem Biophys Res Commun 266: 518-522, 1999.
144.Desaphy JF, Pierno S, Leoty C, George AL, Jr, De Luca A, and Camerino DC. Skeletal muscle disuse induces fibre type-dependent enhancement of Na(+) channel expression. Brain 124: 1100-1113, 2001.
145.Desaphy JF, Pierno S, Liantonio A, De Luca A, Leoty C, and Conte Camerino D. Comparison of excitability parameters and sodium channel behavior of fast- and slow-twitch rat skeletal muscles for the study of the effects of hindlimb suspension, a model of hypogravity. J Gravit Physiol 5: 77-78, 1998.
146.Deschenes MR, Britt AA, and Chandler WC. A comparison of the effects of unloading in young adult and aged skeletal muscle. Med Sci Sports Exerc 33: 1477-1483, 2001.
147.Desplanches D. Structural and functional adaptations of skeletal muscle to weightlessness. Int J Sports Med 18: S259-264, 1997.
148.Desplanches D, Favier R, Sempore B, and Hoppeler H. Whole body and muscle respiratory capacity with dobutamine and hindlimb suspension. J Appl Physiol 71: 2419-2424, 1991.
149.Desplanches D, Kayar SR, Sempore B, Flandrois R, and Hoppeler H. Effect of simulated microgravity on the ultrastructural composition of rat soleus muscle. Physiologist 33: S84-85, 1990.
150.Desplanches D, Kayar SR, Sempore B, Flandrois R, and Hoppeler H. Rat soleus muscle ultrastructure after hindlimb suspension. J Appl Physiol 69: 504-508, 1990.
151.Desplanches D, Mayet MH, Sempore B, and Flandrois R. Structural and functional responses to prolonged hindlimb suspension in rat muscle. J Appl Physiol 63: 558-563, 1987.
152.Desplanches D, Mayet MH, Sempore B, Frutoso J, and Flandrois R. Effect of spontaneous recovery or retraining after hindlimb suspension on aerobic capacity. J Appl Physiol 63: 1739-1743, 1987.
153.di Maso NA, Haddad F, Zeng M, McCue SA, and Baldwin KM. Role of denervation in modulating IIb MHC gene expression in response to T(3) plus unloading state. J Appl Physiol 88: 682-689, 2000.
154.Diffee GM, Caiozzo VJ, Herrick RE, and Baldwin KM. Contractile and biochemical properties of rat soleus and plantaris after hindlimb suspension. Am J Physiol 260: C528-534, 1991.
155.Diffee GM, Caiozzo VJ, McCue SA, Herrick RE, and Baldwin KM. Activity-induced regulation of myosin isoform distribution: comparison of two contractile activity programs. J Appl Physiol 74: 2509-2516, 1993.
156.Diffee GM, Haddad F, Herrick RE, and Baldwin KM. Control of myosin heavy chain expression: interaction of hypothyroidism and hindlimb suspension. Am J Physiol 261: C1099-1106, 1991.
157.Diffee GM, McCue S, LaRosa A, Herrick RE, and Baldwin KM. Interaction of various mechanical activity models in regulation of myosin heavy chain isoform expression. J Appl Physiol 74: 2517-2522, 1993.
158.Dillaman RM, Roer RD, and Gay DM. Fluid movement in bone: theoretical and empirical. J Biomech 24: 163-177, 1991.
159.Dong Q, Shen X, Chen J, Yang G, Meng J, and Xiang Q. Effects of simulated weightlessness on erythrocyte deformability in rats. Space Med Med Eng (Beijing) 10: 240-244, 1997.
160.Doty SB, and Morey-Holton ER. Changes in osteoblastic activity due to simulated weightless conditions. Physiologist 25: S131-132, 1982.
161.Doty SB, Morey-Holton ER, Durnova GN, and Kaplansky AS. Morphological studies of bone and tendon. J Appl Physiol 73: 10S-13S, 1992.
162.Drissi H, Lomri A, Lasmoles F, Holy X, Zerath E, and Marie PJ. Skeletal unloading induces biphasic changes in insulin-like growth factor-I mRNA levels and osteoblast activity. Exp Cell Res 251: 275-284, 1999.
163.Dubouchaud H, Granier P, Mercier J, Le Peuch C, and Prefaut C. Lactate uptake by skeletal muscle sarcolemmal vesicles decreases after 4 wk of hindlimb unweighting in rats. J Appl Physiol 80: 416-421, 1996.
164.Dubouchaud H, Granier P, Mercier J, and Prefaut C. [Effect of hypodynamia on initial speed of lactate transport in skeletal muscle sarcolemmal vesicles in rats]. C R Seances Soc Biol Fil 189: 339-346, 1995.
165.Duke PJ, and Montufar-Solis D. Exposure to altered gravity affects all stages of endochondral cartilage differentiation. Adv Space Res 24: 821-827, 1999.
166.Dunbar SL, Berkowitz DE, Brooks-Asplund EM, and Shoukas AA. The effects of hindlimb unweighting on the capacitance of rat small mesenteric veins. J Appl Physiol 89: 2073-2077, 2000.
167.Dunlap AW, Thomason DB, Menon V, and Hofmann PA. Decreased Ca2+ sensitivity of isometric tension in skinned cardiac myocytes from tail-suspended rats. J Appl Physiol 80: 1612-1617, 1996.
168.Dunn CD, Johnson PC, and Lange RD. Hematopoiesis in antiorthostatic, hypokinesic rats. Physiologist 26: S133-134, 1983.
169.Dunn CD, Johnson PC, and Lange RD. Regulation of hematopoiesis in rats exposed to antiorthostatic hypokinetic/hypodynamia: II. Mechanisms of the "anemia". Aviat Space Environ Med 57: 36-44, 1986.
170.Dunn CD, Johnson PC, Lange RD, Perez L, and Nessel R. Regulation of hematopoiesis in rats exposed to antiorthostatic, hypokinetic/hypodynamia: I. Model description. Aviat Space Environ Med 56: 419-426, 1985.
171.Dunn CDR, Johnson PC, and Leach CS. Fluid Shifts and Erythropoiesis: relevance to the "anemia" of space flight. Physiologist 25: S79-80, 1982.
172.Durnova G, Ilyina-Kakueva E, and Morukov B. The effect of Lodronat(R) on development of osteoporosis in tail-suspended rats. J Gravit Physiol 4: 131-132, 1997.
173.Durnova GN, Burkovskaia TE, and Kaplanskii AS. [The healing of bone fractures in rats during the readaptation after a 14-day head-down suspension]. Aviakosm Ekolog Med 26: 57-59, 1992.
174.Durnova GN, Burkovskaia TE, Vorotnikova EV, Kaplanskii AS, and Arustamov OV. [The effect of weightlessness on fracture healing of rats flown on the biosatellite Cosmos-2044]. Kosm Biol Aviakosm Med 25: 29-33, 1991.
175.Durnova GN, and Kaplanskii AS. [Effect of ephedrine and support loads on development of osteopenia and growth of shin bones in suspended rats]. Aviakosm Ekolog Med 32: 27-31, 1998.
176.Durnova GN, Sakharova ZF, Kaplanskii AS, Ivanov VM, and Khaidakov MS. [Quantitative study of the osteoblasts and osteoclasts in the bones of rats during the simulation of weightlessness]. Kosm Biol Aviakosm Med 20: 37-41, 1986.
177.Durnova GN, Vorotnikova EV, and Prodan NG. [Comparative evaluation of the stress reaction of rats under different methods of simulating the effects of weightlessness]. Kosm Biol Aviakosm Med 21: 79-81, 1987.
178.Ehara Y, Takahashi H, Hanahisa Y, and Yamaguchi M. Effect of vitamin K2 (menaquinone-7) on bone metabolism in the femoral-metaphyseal tissues of normal and skeletal-unloaded rats: enhancement with zinc. Res Exp Med (Berl) 196: 171-178, 1996.
179.Ehara Y, and Yamaguchi M. Histomorphological confirmation of bone loss in the femoral-metaphyseal tissues of rats with skeletal unloading. Res Exp Med (Berl) 196: 163-170, 1996.
180.Ehara Y, and Yamaguchi M. Zinc stimulates protein synthesis in the femoral-metaphyseal tissues of normal and skeletally unloaded rats. Res Exp Med (Berl) 196: 363-372, 1997.
181.el Fazaa S, Gharbi N, Gauquelin G, Gharib C, and Kamoun A. [Effects of simulated weightlessness on the hypophyseal-cortical-adrenal axis in the pregnant rat]. Arch Physiol Biochem 105: 53-57, 1997.
182.Elder GC. Effects of hind limb suspension on the development of dystrophic hamster muscle. Exp Neurol 99: 187-200, 1988.
183.Elder GC, and McComas AJ. Development of rat muscle during short- and long-term hindlimb suspension. J Appl Physiol 62: 1917-1923, 1987.
184.Elkhammari A, Noireaud J, and Leoty C. Changes of contractile responses due to simulated weightlessness in rat soleus muscle. Adv Space Res 14: 377-380, 1994.
185.Ellis S, Giometti CS, and Riley DA. Changes in muscle protein composition induced by disuse atrophy: analysis by two-dimensional electrophoresis. Physiologist 28: S159-160, 1985.
186.Esser KA, and White TP. Mechanical load affects growth and maturation of skeletal muscle grafts. J Appl Physiol 78: 30-37, 1995.
187.Evans J, Mulenburg GM, Harper JS, Skundberg TL, Navidi M, and Arnaud SB. A metabolic cage for the hindlimb suspended rat. NASA Ames Research Center, 1994, p. 1-46.
188.Fagette S, Fareh J, Cottet-Emard JM, Pequignot JM, Gauquelin G, and Gharib C. Effects of a short term hindlimb suspension on central and peripheral norepinephrine turnover in rats. Life Sci 53: 555-561, 1993.
189.Fagette S, Lo M, Gharib C, and Gauquelin G. Cardiovascular variability and baroreceptor reflex sensitivity over a 14-day tail suspension in rats. J Appl Physiol 78: 717-724, 1995.
190.Fagette S, Lo M, Gharib C, and Gauquelin G. Sympathetic nervous activity and cardiovascular variability after a 3-day tail suspension in rats. Eur J Appl Physiol Occup Physiol 69: 480-487, 1994.
191.Fagette S, Somody L, Bouzeghrane F, Cottet-Emard JM, Gharib C, and Gauquelin G. Central and peripheral sympathetic activities in rats during recovery from simulated weightlessness. J Appl Physiol 79: 1991-1997, 1995.
192.Fagette S, Somody L, Koubi H, Fareh J, Viso M, Gharib C, and Gauquelin G. Central and peripheral noradrenergic responses to 14 days of spaceflight (SLS-2) or hindlimb suspension in rats. Aviat Space Environ Med 67: 458-462, 1996.
193.Falempin M, Fodili S, Leterme D, and Mounier Y. Functional effects of uridine triphosphate on the atrophied soleus muscle of rat after unloading. Muscle Nerve 20: 172-178, 1997.
194.Falempin M, and In-Albon SF. Influence of brief daily tendon vibration on rat soleus muscle in non-weight-bearing situation. J Appl Physiol 87: 3-9, 1999.
195.Fareh J, Bayard B, Gabrion J, Thibault G, Oliver J, Bouille C, Gauquelin G, and Gharib C. Cardiac and plasma atrial natriuretic peptide after 9-day hindlimb suspension in rats. J Appl Physiol 76: 641-649, 1994.
196.Fareh J, Cottet-Emard JM, Fagette S, Pequignot JM, and Gharib C. Central and peripheral norepinephrine turnover after hindlimb suspension in the rat. Aviat Space Environ Med 64: 386-391, 1993.
197.Fareh J, Fagette S, Cottet-Emard JM, Allevard AM, Viso M, Gauquelin G, and Gharib C. Comparison of the effects of spaceflight and hindlimb-suspension on rat pituitary vasopressin and brainstem norepinephrine content. Adv Space Res 14: 365-371, 1994.
198.Fauteck SP, and Kandarian SC. Sensitive detection of myosin heavy chain composition in skeletal muscle under different loading conditions. Am J Physiol 268: C419-424, 1995.
199.Feldman S, and Brunner LJ. Small animal model of weightlessness for pharmacokinetic evaluation. J Clin Pharmacol 34: 677-683, 1994.
200.Fell RD, Gladden LB, Steffen JM, and Musacchia XJ. Fatigue and contraction of slow and fast muscles in hypokinetic/hypodynamic rats. J Appl Physiol 58: 65-69, 1985.
201.Fell RD, Steffen JM, and Musacchia XJ. Effect of hypokinesia-hypodynamia on rat muscle oxidative capacity and glucose uptake. Am J Physiol 249: R308-312, 1985.
202.Fidelina OV, Gorbatiuk OS, Adamskaia EI, and Akmaev IG. [The participation of the nontraditional neuromediator nitric oxide in the mechanisms of adaptation to extreme conditions]. Usp Fiziol Nauk 30: 41-49, 1999.
203.Fielder PJ, Morey ER, and Roberts WE. Osteoblast histogenesis in periodontal ligament and tibial metaphysis during simulated weightlessness. Aviat Space Environ Med 57: 1125-1130, 1986.
204.Fisher JS, Hasser EM, and Brown M. Effects of ovariectomy and hindlimb unloading on skeletal muscle. J Appl Physiol 85: 1316-1321, 1998.
205.Fitts RH, Brimmer CJ, Heywood-Cooksey A, and Timmerman RJ. Single muscle fiber enzyme shifts with hindlimb suspension and immobilization. Am J Physiol 256: C1082-1091, 1989.
206.Fitts RH, McDonald KS, and Schluter JM. The determinants of skeletal muscle force and power: their adaptability with changes in activity pattern. J Biomech 24: 111-122, 1991.
207.Fitts RH, Metzger JM, Riley DA, and Unsworth BR. Models of disuse: a comparison of hindlimb suspension and immobilization. J Appl Physiol 60: 1946-1953, 1986.
208.Fitts RH, Riley DR, and Widrick JJ. Physiology of a microgravity environment invited review: microgravity and skeletal muscle. J Appl Physiol 89: 823-839, 2000.
209.Fleming SD, Rosenkrans CF, Jr, and Chapes SK. Test of the antiorthostatic suspension model on mice: effects on the inflammatory cell response. Aviat Space Environ Med 61: 327-332, 1990.
210.Flynn DE, and Max SR. Effects of suspension hypokinesia/hypodynamia on rat skeletal muscle. Aviat Space Environ Med 56: 1065-1069, 1985.
211.Fournier M, Roy RR, Perham H, Simard CP, and Edgerton VR. Is limb immobilization a model of muscle disuse? Exp Neurol 80: 147-156, 1983.
212.Fowler WM, Jr, Abresch RT, Haida N, Larson DB, Sharman RB, Taylor RG, and Entrikin RK. Effect of hind-limb suspension on young and adult skeletal muscle. II. Dystrophic mice. Exp Neurol 103: 77-82, 1989.
213.Fox RA, Daunton NG, and Corcoran ML. Study of adaptation to altered gravity through systems analysis of motor control. Adv Space Res 22: 245-253, 1998.
214.Fraysse B, Guillet C, Huchet-Cadiou C, Camerino DC, Gascan H, and Leoty C. Ciliary neurotrophic factor prevents unweighting-induced functional changes in rat soleus muscle. J Appl Physiol 88: 1623-1630, 2000.
215.Frenette J, and Tidball JG. Mechanical loading regulates expression of talin and its mRNA, which are concentrated at myotendinous junctions. Am J Physiol 275: C818-825, 1998.
216.Fu CJ, Yang LJ, Cao XS, Chen XZ, and Zhang LF. [Changes of human recombination bone morphogenetic protein-2 in bone and marrow in tail suspended rats]. Space Med Med Eng (Beijing) 14: 295-297, 2001.
217.Furby A, Mounier Y, Stevens L, Leterme D, and Falempin M. Effects of chronic electrostimulation on rat soleus skinned fibers during hindlimb suspension. Muscle Nerve 16: 720-726, 1993.
218.Gabrion J, Herbute S, Oliver J, Maurel D, Davet J, Clavel B, Gharib C, Fareh J, Fagette S, and Nguyen B. Choroidal responses in microgravity. (SLS-1, SLS-2 and hindlimb-suspension experiments). Acta Astronaut 36: 439-448, 1995.
219.Gabrion J, Maurel D, Clavel B, Davet J, Fareh J, Herbute S, O'Mara K, Gharib C, Hinds W, Krasnov I, and Guell A. Changes in apical organization of choroidal cells in rats adapted to spaceflight or head-down tilt. Brain Res 734: 301-315, 1996.
220.Garber MA, McDowell DL, and Hutton WC. Bone loss during simulated weightlessness: a biomechanical and mineralization study in the rat model. Aviat Space Environ Med 71: 586-592, 2000.
221.Gardetto PR, Schluter JM, and Fitts RH. Contractile function of single muscle fibers after hindlimb suspension. J Appl Physiol 66: 2739-2749, 1989.
222.Gardiner PF, Favron M, and Corriveau P. Histochemical and contractile responses of rat medial gastrocnemius to 2 weeks of complete disuse. Can J Physiol Pharmacol 70: 1075-1081, 1992.
223.Gardner JR, Hess CP, Webb AG, Tsika RW, Dawson MJ, and Gulani V. Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity. Magn Reson Med 45: 1122-1125, 2001.
224.Gauquelin G, Kazek C, Allevard AM, Garcin R, Bonnod J, Gutkowska J, Cantin M, and Gharib C. Early (1 to 24h) plasma atrial natriuretic factor changes in the rat during antiorthostatic hypokinetic suspension. Biochem Biophys Res Commun 148: 582-588, 1987.
225.Gauquelin G, Schiffrin EL, Garcia R, Entresangles M, Cantin M, and Gharib C. Specific binding of atrial natriuretic factor to renal glomeruli during day or night antiorthostatic suspension in the rat. Life Sci 43: 1905-1912, 1988.
226.Geary GG, Krause DN, Purdy RE, and Duckles SP. Simulated microgravity increases myogenic tone in rat cerebral arteries. J Appl Physiol 85: 1615-1621, 1998.
227.Gharbi N, El Fazaa S, Fagette S, Gauquelin G, Gharib C, and Kamoun A. Cortico-adrenal function under simulated weightlessness during gestation in the rat--effects on fetal development. J Gravit Physiol 3: 63-68, 1996.
228.Giger JM, Haddad F, Qin AX, and Baldwin KM. In vivo regulation of the beta-myosin heavy chain gene in soleus muscle of suspended and weight-bearing rats. Am J Physiol Cell Physiol 278: C1153-1161, 2000.
229.Gillette PD, and Fell RD. Passive tension in rat hindlimb during suspension unloading and recovery: muscle/joint contributions. J Appl Physiol 81: 724-730, 1996.
230.Girten B, McPherson S, Lee M, Grethe N, McDowell R, McPherson L, and Tuttle RR. Effectiveness of a cytokine restraining agent (CRA (TM)) in attenuating disuse deconditioning induced by hindlimb unloading in rats. J Gravit Physiol 2: 121-122, 1995.
231.Girten B, Oloff C, Plato P, Eveland E, Merola AJ, and Kazarian L. Skeletal muscle antioxidant enzyme levels in rats after simulated weightlessness, exercise and dobutamine. Physiologist 32: S59-60, 1989.
232.Globus RK, Bikle DD, Halloran B, and Morey-Holton E. Skeletal response to dietary calcium in a rat model simulating weightlessness. J Bone Miner Res 1: 191-197, 1986.
233.Globus RK, Bikle DD, and Morey-Holton E. Effects of simulated weightlessness on bone mineral metabolism. Endocrinology 114: 2264-2270, 1984.
234.Globus RK, Bikle DD, and Morey-Holton E. The temporal response of bone to unloading. Endocrinology 118: 733-742, 1986.
235.Goda T, Takase S, Yokogoshi H, Mita T, Isemura M, and Hoshi T. Changes in hepatic metabolism through simulated weightlessness: decrease of glycogen and increase of lipids following prolonged immobilization in the rat. Res Exp Med (Berl) 191: 189-199, 1991.
236.Goldspink DF, Morton AJ, Loughna P, and Goldspink G. The effect of hypokinesia and hypodynamia on protein turnover and the growth of four skeletal muscles of the rat. Pflugers Arch 407: 333-340, 1986.
237.Goldstein MA, Edwards RJ, and Schroeter JP. Cardiac morphology after conditions of microgravity during COSMOS 2044. J Appl Physiol 73: 94S-100S, 1992.
238.Gordon SE, Fluck M, and Booth FW. Selected Contribution: Skeletal muscle focal adhesion kinase, paxillin, and serum response factor are loading dependent. J Appl Physiol 90: 1174-1183; discussion 1165, 2001.
239.Goto Y-I, Kamaki H, Igarashi F, and Nonaka I. Muscle mitochondrial changes by experimental immobility and hindlimb suspension. J Gravit Physiol 7: P109-110, 2000.
240.Gould CL, and Sonnenfeld G. Enhancement of viral pathogenesis in mice maintained in an antiorthostatic suspension model: coordination with effects on interferon production. J Biol Regul Homeost Agents 1: 33-36, 1987.
241.Graham SC, Roy RR, Hauschka EO, and Edgerton VR. Effects of periodic weight support on medial gastrocnemius fibers of suspended rat. J Appl Physiol 67: 945-953, 1989.
242.Graham SC, Roy RR, West SP, Thomason D, and Baldwin KM. Exercise effects on the size and metabolic properties of soleus fibers in hindlimb-suspended rats. Aviat Space Environ Med 60: 226-234, 1989.
243.Grichko VP, Heywood-Cooksey A, Kidd KR, and Fitts RH. Substrate profile in rat soleus muscle fibers after hindlimb unloading and fatigue. J Appl Physiol 88: 473-478, 2000.
244.Grigor'ev AI, Alekseev EI, and Kaplanskii AS. [Functional activity of rat pancreatic endocrine cells in weightlessness and in a suspended state]. Dokl Akad Nauk 363: 267-270, 1998.
245.Grigorian SS, Sokolova IA, Shakhnazarov AA, Rudneva RI, and Timkina MI. [Influence of polyethylene oxide Polyox WSR-301 on the pressure in mesenteric arterial microvessels in rats pre-adapted to anti-orthostatic states]. Aviakosm Ekolog Med 32: 77-79, 1998.
246.Grigoriev A, Morukov B, Stupakov G, and Bobrovnik E. Influence of bisphosphonates on calcium metabolism and bone tissue during simulation of the physiological effects of microgravity. J Gravit Physiol 5: 69-70, 1998.
247.Grindeland RE, Roy RR, Edgerton VR, Grossman EJ, Mukku VR, Jiang B, Pierotti DJ, and Rudolph I. Interactive effects of growth hormone and exercise on muscle mass in suspended rats. Am J Physiol 267: R316-322, 1994.
248.Grossman EJ, Grindeland RE, Roy RR, Talmadge RJ, Evans J, and Edgerton VR. Growth hormone, IGF-I, and exercise effects on non-weight-bearing fast muscles of hypophysectomized rats. J Appl Physiol 83: 1522-1530, 1997.
249.Guezennec CY, Gilson E, and Serrurier B. Comparative effects of hindlimb suspension and exercise on skeletal muscle myosin isozymes in rats. Eur J Appl Physiol Occup Physiol 60: 430-435, 1990.
250.Guillet C, Huchet-Cadiou C, Gascan H, and Leoty C. Changes in CNTF receptor alpha expression in rat skeletal muscle during the recovery period after hindlimb suspension. Acta Physiol Scand 163: 273-278, 1998.
251.Gupta RC, Misulis KE, and Dettbarn WD. Activity dependent characteristics of fast and slow muscle: biochemical and histochemical considerations. Neurochem Res 14: 647-655, 1989.
252.Gupta RC, Misulis KE, and Dettbarn WD. Changes in the cholinergic system of rat sciatic nerve and skeletal muscle following suspension-induced disuse. Exp Neurol 89: 622-633, 1985.
253.Haddad F, Qin AX, Zeng M, McCue SA, and Baldwin KM. Interaction of hyperthyroidism and hindlimb suspension on skeletal myosin heavy chain expression. J Appl Physiol 85: 2227-2236, 1998.
254.Hadley JA, Hall JC, O'Brien A, and Ball R. Effects of a simulated microgravity model on cell structure and function in rat testis and epididymis. J Appl Physiol 72: 748-759, 1992.
255.Haida N, Fowler WM, Jr, Abresch RT, Larson DB, Sharman RB, Taylor RG, and Entrikin RK. Effect of hind-limb suspension on young and adult skeletal muscle. I. Normal mice. Exp Neurol 103: 68-76, 1989.
256.Halet G, Viard P, Morel JL, Mironneau J, and Mironneau C. Effects of hindlimb suspension on cytosolic Ca2+ and [3H]ryanodine binding in cardiac myocytes. Am J Physiol 276: H1131-1136, 1999.
257.Halloran BP, Bikle DD, Cone CM, and Morey-Holton E. Glucocorticoids and inhibition of bone formation induced by skeletal unloading. Am J Physiol 255: E875-879, 1988.
258.Halloran BP, Bikle DD, Harris J, Autry CP, Currier PA, Tanner S, Patterson-Buckendahl P, and Morey-Holton E. Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone. J Bone Miner Res 10: 1168-1176, 1995.
259.Halloran BP, Bikle DD, Harris J, Foskett HC, and Morey-Holton E. Skeletal unloading decreases production of 1,25-dihydroxyvitamin D. Am J Physiol 264: E712-716, 1993.
260.Halloran BP, Bikle DD, Harris J, Tanner S, Curren T, and Morey-Holton E. Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading. J Bone Miner Res 12: 1068-1074, 1997.
261.Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, and Morey-Holton E. Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolism. Physiologist 28: S127-128, 1985.
262.Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, and Morey-Holton E. The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading. Endocrinology 118: 948-954, 1986.
263.Hargens AR, and Mahmood M. Decreased swelling pressure of rat nucleus pulposus associated with simulated weightlessness. Physiologist 32: S23-24, 1989.
264.Hargens AR, Steskal J, Johansson C, and Tipton CM. Tissue fluid shift, forelimb loading, and tail tension in tail-suspended rats. Physiologist 27: S37-38, 1984.
265.Hargens AR, Steskal J, and Morey-Holton ER. Transient dehydration of lungs in tail-suspended rats. Physiologist 28: S155-156, 1985.
266.Harjola VP, Jankala H, and Harkonen M. The effect of androgen status on skeletal muscle myosin heavy chain mRNA and protein levels in rats recovering from immobilization. Eur J Appl Physiol 83: 427-433, 2000.
267.Harper JS, Mulenburg GM, Evans J, Navidi M, Wolinsky I, and Arnaud SB. Metabolic cages for a space flight model in the rat. Lab Anim Sci 44: 645-647, 1994.
268.Hasser EM, and Moffitt JA. Regulation of sympathetic nervous system function after cardiovascular deconditioning. Ann N Y Acad Sci 940: 454-468, 2001.
269.Hauschka EO, Roy RR, and Edgerton VR. Periodic weight support effects on rat soleus fibers after hindlimb suspension. J Appl Physiol 65: 1231-1237, 1988.
270.Hauschka EO, Roy RR, and Edgerton VR. Size and metabolic properties of single muscle fibers in rat soleus after hindlimb suspension. J Appl Physiol 62: 2338-2347, 1987.
271.Hayase K, and Yokogoshi H. Effect of suspension hypokinesia/hypodynamia on tissue protein turnover in rats. Jpn J Physiol 41: 473-482, 1991.
272.Hays AM, Keller RL, Gmitro AF, Alpbach MI, Sridhar KR, Balagtas MP, and Witten ML. Quantitative phase contrast images to quantitate flow in a rat model of microgravity. Aviat Space Environ Med 70: 225-229, 1999.
273.Henriksen EJ, Kirby CR, and Tischler ME. Glycogen supercompensation in rat soleus muscle during recovery from nonweight bearing. J Appl Physiol 66: 2782-2787, 1989.
274.Henriksen EJ, Munoz KA, Aannestad AT, and Tischler ME. Cardiac protein content and synthesis in vivo after voluntary running or head-down suspension. J Appl Physiol 76: 2814-2819, 1994.
275.Henriksen EJ, and Ritter LS. Effect of insulin-like factors on glucose transport activity in unweighted rat skeletal muscle. J Appl Physiol 75: 820-824, 1993.
276.Henriksen EJ, and Ritter LS. Effect of soleus unweighting on stimulation of insulin-independent glucose transport activity. J Appl Physiol 74: 1653-1657, 1993.
277.Henriksen EJ, Rodnick KJ, Mondon CE, James DE, and Holloszy JO. Effect of denervation or unweighting on GLUT-4 protein in rat soleus muscle. J Appl Physiol 70: 2322-2327, 1991.
278.Henriksen EJ, Satarug S, Tischler ME, and Furst P. Responses of lysosomal and non-lysosomal proteases to unloading of the soleus. Adv Exp Med Biol 240: 235-242, 1988.
279.Henriksen EJ, Stump CS, Trinh TH, and Beaty SD. Role of glucose transport in glycogen supercompensation in reweighted rat skeletal muscle. J Appl Physiol 80: 1540-1546, 1996.
280.Henriksen EJ, and Tischler ME. Glucose uptake in rat soleus: effect of acute unloading and subsequent reloading. J Appl Physiol 64: 1428-1432, 1988.
281.Henriksen EJ, and Tischler ME. Possible mechanism for changes in glycogen metabolism in unloaded soleus muscle. Physiologist 28: S131-132, 1985.
282.Henriksen EJ, and Tischler ME. Time course of the response of carbohydrate metabolism to unloading of the soleus. Metabolism 37: 201-208, 1988.
283.Henriksen EJ, Tischler ME, Jacob S, and Cook PH. Muscle protein and glycogen responses to recovery from hypogravity and unloading by tail-cast suspension. Physiologist 28: S193-194, 1985.
284.Henriksen EJ, Tischler ME, and Johnson DG. Increased response to insulin of glucose metabolism in the 6-day unloaded rat soleus muscle. J Biol Chem 261: 10707-10712, 1986.
285.Henriksen EJ, Tischler ME, Woodman CR, Munoz KA, Stump CS, and Kirby CR. Elevated interstitial fluid volume in soleus muscles unweighted by spaceflight or suspension. J Appl Physiol 75: 1650-1653, 1993.
286.Herbert ME, Roy RR, and Edgerton VR. Influence of one-week hindlimb suspension and intermittent high load exercise on rat muscles. Exp Neurol 102: 190-198, 1988.
287.Holy X, and Zerath E. [The suspension device for hindlimb unloading in the rat--results of a video monitoring study]. Stal 21: 177-184, 1996.
288.Holy X, Zerath E, Francois A, Facy P, Malouvier A, and Nogues C. Changes in rat atrial ANF granules induced by hindlimb suspension. Regul Pept 54: 417-428, 1994.
289.Hornberger TA, Hunter RB, Kandarian SC, and Esser KA. Regulation of translation factors during hindlimb unloading and denervation of skeletal muscle in rats. Am J Physiol Cell Physiol 281: C179-187, 2001.
290.Howard G, Steffen JM, and Geoghegan TE. Transcriptional regulation of decreased protein synthesis during skeletal muscle unloading. J Appl Physiol 66: 1093-1098, 1989.
291.Huchet-Cadiou C, Bonnet V, Meme W, and Leoty C. Hypogravity increases cyclopiazonic acid sensitivity of rat soleus muscle. J Appl Physiol 80: 1100-1104, 1996.
292.Huckstorf BL, Slocum GR, Bain JL, Reiser PM, Sedlak FR, Wong-Riley MT, and Riley DA. Effects of hindlimb unloading on neuromuscular development of neonatal rats. Brain Res Dev Brain Res 119: 169-178, 2000.
293.Hunter RB, Mitchell-Felton H, Essig DA, and Kandarian SC. Expression of endoplasmic reticulum stress proteins during skeletal muscle disuse atrophy. Am J Physiol Cell Physiol 281: C1285-1290, 2001.
294.Hymer WC, Grindeland R, Krasnov I, Victorov I, Motter K, Mukherjee P, Shellenberger K, and Vasques M. Effects of spaceflight on rat pituitary cell function. J Appl Physiol 73: 151S-157S, 1992.
295.Hymer WC, and Grindeland RE. The pituitary: aging and spaceflown rats. Exp Gerontol 26: 257-265, 1991.
296.Il'in EA, and Kaplanskii AS. [Comparative analysis of changes in rats organisms exposed to microgravity and head-down suspension]. Aviakosm Ekolog Med 32: 43-50, 1998.
297.Il'in EA, and Novikov VE. [Stand for modelling the physiological effects of weightlessness in laboratory experiments with rats]. Kosm Biol Aviakosm Med 14: 79-80, 1980.
298.Il'ina-Kakueva EI, and Burkovskaia TE. [The characteristics of the reparative process in the muscles when deprived of their functional loads]. Aviakosm Ekolog Med 26: 39-42, 1992.
299.Il'ina-Kakueva EI, and Kaplanskii AS. [The effect of support loads and CNS stimulants on the development of the atrophic process in the muscles of suspended rats]. Aviakosm Ekolog Med 33: 20-25, 1999.
300.Il'ina-Kakueva EI, and Krasnov IB. [Dynamics of atrophic processes in the rat's muscles under the deficiency of support loads]. Aviakosm Ekolog Med 32: 41-44, 1998.
301.Il'ina-Kakueva EI, and Novikov VE. [Skeletal musculature of rats during modeling of the physiological effects of weightlessness (morphological study)]. Kosm Biol Aviakosm Med 19: 56-60, 1985.
302.Ingalls CP, Warren GL, and Armstrong RB. Intracellular Ca2+ transients in mouse soleus muscle after hindlimb unloading and reloading. J Appl Physiol 87: 386-390, 1999.
303.Ingalls CP, Wenke JC, and Armstrong RB. Time course changes in [Ca2+]i, force, and protein content in hindlimb-suspended mouse soleus muscles. Aviat Space Environ Med 72: 471-476, 2001.
304.Ishihara A, Oishi Y, Roy RR, and Edgerton VR. Influence of two weeks of non-weight bearing on rat soleus motoneurons and muscle fibers. Aviat Space Environ Med 68: 421-425, 1997.
305.Ishihara H, Asano T, Katagiri H, Lin JL, Tsukuda K, Inukai K, Yazaki Y, and Oka Y. Expression of GLUT-4 glucose transporter in unweighted soleus muscle of normal and STZ-induced diabetic rats. Am J Physiol 264: E301-307, 1993.
306.Ishijima M, Rittling SR, Yamashita T, Tsuji K, Kurosawa H, Nifuji A, Denhardt DT, and Noda M. Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. J Exp Med 193: 399-404, 2001.
307.Jain PK, Banerjee PK, Baboo NS, and Iyer EM. Physiological properties of rat hind limb muscles after 15 days of simulated weightless environment. Indian J Physiol Pharmacol 41: 23-28, 1997.
308.Jain PK, Iyer EM, Banerjee PK, and Baboo NS. Bone changes during simulated weightlessness in rats. Indian J Physiol Pharmacol 44: 359-362, 2000.
309.Jaspers SR, Fagan JM, Satarug S, Cook PH, and Tischler ME. Effects of immobilization on rat hind limb muscles under non-weight-bearing conditions. Muscle Nerve 11: 458-466, 1988.
310.Jaspers SR, Fagan JM, and Tischler ME. Biochemical response to chronic shortening in unloaded soleus muscles. J Appl Physiol 59: 1159-1163, 1985.
311.Jaspers SR, Henriksen E, Jacob S, and Tischler ME. Metabolism of branched-chain amino acids in leg muscles from tail-cast suspended intact and adrenalectomized rats. Metabolism 38: 109-114, 1989.
312.Jaspers SR, Henriksen EJ, Satarug S, and Tischler ME. Effects of stretching and disuse on amino acids in muscles of rat hind limbs. Metabolism 38: 303-310, 1989.
313.Jaspers SR, Jacob S, and Tischler ME. Metabolism of amino acids by the atrophied soleus of tail-casted, suspended rats. Metabolism 35: 216-223, 1986.
314.Jaspers SR, and Tischler ME. Atrophy and growth failure of rat hindlimb muscles in tail-cast suspension. J Appl Physiol 57: 1472-1479, 1984.
315.Jaspers SR, and Tischler ME. Insulin effect on amino acid uptake by unloaded rat hindlimb muscles. Horm Metab Res 20: 125-126, 1988.
316.Jaspers SR, and Tischler ME. Role of glucocorticoids in the response of rat leg muscles to reduced activity. Muscle Nerve 9: 554-561, 1986.
317.Jasperse JL, Woodman CR, Price EM, Hasser EM, and Laughlin MH. Hindlimb unweighting decreases ecNOS gene expression and endothelium-dependent dilation in rat soleus feed arteries. J Appl Physiol 87: 1476-1482, 1999.
318.Jiang B, Ohira Y, Roy RR, Nguyen Q, Ilyina-Kakueva EI, Oganov V, and Edgerton VR. Adaptation of fibers in fast-twitch muscles of rats to spaceflight and hindlimb suspension. J Appl Physiol 73: 58S-65S, 1992.
319.Jiang B, Roy RR, Polyakov IV, Krasnov IB, and Edgerton VR. Ventral horn cell responses to spaceflight and hindlimb suspension. J Appl Physiol 73: 107S-111S, 1992.
320.Jordan JP, Sykes HA, Crownover JC, Schatte CL, Simmons JB, 2nd, and Jordan DP. Effect of simulated weightlessness on energy metabolism in the rat. Physiologist 22: S69-70, 1979.
321.Jordan JP, Sykes HA, Crownover JC, Schatte CL, Simmons JB, 2nd, and Jordan DP. Simulated weightlessness: effects of bioenergetic balance. Aviat Space Environ Med 51: 132-136, 1980.
322.Kahwaji CI, Sangha DS, Sheibani S, Ashori M, Nguyen H, Kim Y, and Purdy RE. Simulated microgravity-induced vascular hyporesponsiveness: role of signal transduction. Proc West Pharmacol Soc 42: 9-12, 1999.
323.Kahwaji CI, Sheibani S, Han S, Siu WO, Kaka AH, Fathy TM, el-Abbadi NH, and Purdy RE. Evidence that simulated microgravity may alter the vascular nonreceptor tyrosine kinase second messenger pathway. Proc West Pharmacol Soc 43: 75-77, 2000.
324.Kandarian S, O'Brien S, Thomas K, Schulte L, and Navarro J. Regulation of skeletal muscle dihydropyridine receptor gene expression by biomechanical unloading. J Appl Physiol 72: 2510-2514, 1992.
325.Kandarian SC, Boushel RC, Schulte LM, Jaspers SR, Fagan JM, Satarug S, Cook PH, and Tischler ME. Elevated interstitial fluid volume in rat soleus muscles by hindlimb unweighting. J Appl Physiol 71: 910-914, 1991.
326.Kandarian SC, Peters DG, Favero TG, Ward CW, and Williams JH. Adaptation of the skeletal muscle calcium-release mechanism to weight-bearing condition. Am J Physiol 270: C1588-1594, 1996.
327.Kano Y, Shimegi S, Takahashi H, Masuda K, and Katsuta S. Changes in capillary luminal diameter in rat soleus muscle after hind-limb suspension. Acta Physiol Scand 169: 271-276, 2000.
328.Kaplanski IA, Il'ina-Kakueva EI, Durnova GN, Alekseev EA, and Loginov VI. [Effect of gravitation loading and retabolil on development of atrophy in muscles and bones of rats due to suspension]. Aviakosm Ekolog Med 33: 48-53, 1999.
329.Kaplanskii AS, Durnova GN, Ili'ina-Kakueva EI, and Loginov VI. [Role of growth hormone underproduction and support load deficit in development of muscle atrophy and osteopenia in tail-suspended rats]. Aviakosm Ekolog Med 33: 20-24, 1999.
330.Kaplanskii AS, Grindeland RE, Il'ina-Kakueva EI, Durnova GN, and Grossman ED. [Role of the hypophysis, hormonal growth inducers and physical exercises in the regulation of function of thyrocytes, C-cells and parathyrocytes in rats during simulated weightlessness]. Aviakosm Ekolog Med 29: 47-52, 1995.
331.Kaplanskii AS, Sakharova ZF, El'ina-Kakueva EI, and Dyrnova GN. [Morphological study of early changes in rat bones during exposure to simulated weightlessness]. Kosm Biol Aviakosm Med 21: 36-39, 1987.
332.Kasper CE. Recovery of plantaris muscle from impaired physical mobility. Biol Res Nurs 1: 4-11, 1999.
333.Kasper CE. Sarcolemmal disruption in reloaded atrophic skeletal muscle. J Appl Physiol 79: 607-614, 1995.
334.Kasper CE. Spatial patterns of atrophied muscle fibers during exercised recovery. Biol Res Nurs 1: 38-47, 1999.
335.Kasper CE, McNulty AL, Otto AJ, and Thomas DP. Alterations in skeletal muscle related to impaired physical mobility: an empirical model. Res Nurs Health 16: 265-273, 1993.
336.Kasper CE, St Pierre B, Fuchs A, and Garfinkel A. Spatial patterns of fiber types in atrophied skeletal muscle. West J Nurs Res 17: 49-62; discussion 101-111, 1995.
337.Kasper CE, White TP, and Maxwell LC. Running during recovery from hindlimb suspension induces transient muscle injury. J Appl Physiol 68: 533-539, 1990.
338.Kasper CE, and Xun L. Cytoplasm-to-myonucleus ratios following microgravity. J Muscle Res Cell Motil 17: 595-602, 1996.
339.Kasper CE, and Xun L. Cytoplasm-to-myonucleus ratios in plantaris and soleus muscle fibres following hindlimb suspension. J Muscle Res Cell Motil 17: 603-610, 1996.
340.Kasper CE, and Xun L. Expression of titin in skeletal muscle varies with hind-limb unloading. Biol Res Nurs 2: 107-115, 2000.
341.Kastello GM, and Sothmann MS. Brain norepinephrine changes with simulated weightlessness and relation to exercise training. Physiol Behav 66: 885-891, 1999.
342.Kawano F, Nomura T, Kang MS, Lee JH, Han EY, Chiu YC, Sato Y, Ishihara A, and Ohira Y. Effects of 9 weeks of hinglimb unloading on motor performances in adult rats. J Gravit Physiol 7: P115-116, 2000.
343.Kawano S, Kanda K, Ohmori S, Izumi R, Yasukawa K, Murata Y, and Seo H. Effect of estrogen on the development of disuse atrophy of bone and muscle induced by tail-supension in rats. Environ Med 41: 89-92, 1997.
344.Kawata T, Fujita T, Tokimasa C, Kawasoko S, Kaku M, Sugiyama H, Niida S, and Tanne K. Suspension "hypokinesia/hypodynamia" may decrease bone mass by stimulating osteoclast production in ovariectomized mice. J Nutr Sci Vitaminol (Tokyo) 44: 581-590, 1998.
345.Kazakova RT, and Badakva AM. [Effects of isolated and combined effects of a constant magnetic field and antiorthostatic hypokinesia on central hemodynamics in rats]. Kosm Biol Aviakosm Med 25: 48-49, 1991.
346.Keil L, Evans J, Grindeland R, and Krasnov I. Pituitary oxytocin and vasopressin content of rats flown on COSMOS 2044. J Appl Physiol 73: 166S-168S, 1992.
347.Kell R, Pierce H, and Swoap SJ. PGAM-M expression is regulated pretranslationally in hindlimb muscles and under altered loading conditions. J Appl Physiol 86: 236-242, 1999.
348.Khammari A, and Noireaud J. Changes in potassium contractures due to simulated weightlessness in rat soleus muscle. J Appl Physiol 77: 2420-2425, 1994.
349.Kharchenko I, Tarasova O, Borovik A, and Vinogradova O. Dynamics of blood pressure and pulse interval duration in rats after 14 day suspension. J Gravit Physiol 6: P113-114, 1999.
350.Kharchenko I, Tarasova O, Zotov A, Borovik A, and Vinogradova O. Regulation of hemodynamics in sympathectomized rats after adaptation to tail suspension. J Gravit Physiol 7: P139-140, 2000.
351.Kidder LS, Klein GL, Stuart CA, Lee TC, Gundberg CM, Alcock N, Cooper CW, and Simmons DJ. Skeletal effects of sodium fluoride during hypokinesia. Bone Miner 11: 305-318, 1990.
352.Kinoue T. [Can a tail-suspension model be applied to simulate the reproduction system under weightlessness?]. Nichidai Igaku Zasshi 55: 549-559, 1996.
353.Kirby CR, Ryan MJ, and Booth FW. Eccentric exercise training as a countermeasure to non-weight-bearing soleus muscle atrophy. J Appl Physiol 73: 1894-1899, 1992.
354.Kirby CR, and Tischler ME. Beta-adrenergic effects on carbohydrate metabolism in the unweighted rat soleus muscle. J Appl Physiol 69: 2113-2119, 1990.
355.Kirby CR, Woodman CR, Woolridge D, and Tischler ME. Cyclic adenosine monophosphate accumulation and beta-adrenergic binding in unweighted and denervated rat soleus muscle. Metabolism 41: 793-799, 1992.
356.Kirchen ME, O'Connor KM, Gruber HE, Sweeney JR, Fras IA, Stover SJ, Sarmiento A, and Marshall GJ. Effects of microgravity on bone healing in a rat fibular osteotomy model. Clin Orthop: 231-242, 1995.
357.Kischel P, Bastide B, Stevens L, and Mounier Y. Expression and functional behavior of troponin C in soleus muscle fibers of rat after hindlimb unloading. J Appl Physiol 90: 1095-1101, 2001.
358.Kodama Y, Nakayama K, Fuse H, Fukumoto S, Kawahara H, Takahashi H, Kurokawa T, Sekiguchi C, Nakamura T, and Matsumoto T. Inhibition of bone resorption by pamidronate cannot restore normal gain in cortical bone mass and strength in tail-suspended rapidly growing rats. J Bone Miner Res 12: 1058-1067, 1997.
359.Koebel DA, Fell RD, and Steffen JM. Increased glucose and 2-deoxy-D-glucose uptake in skeletal muscle of suspended rats. Aviat Space Environ Med 64: 1016-1022, 1993.
360.Kopydlowski KM, McVey DS, Woods KM, Iandolo JJ, and Chapes SK. Effects of antiorthostatic suspension and corticosterone on macrophage and spleen cell function. J Leukoc Biol 52: 202-208, 1992.
361.Kostenuik PJ, Halloran BP, Morey-Holton ER, and Bikle DD. Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells. Am J Physiol 273: E1133-1139, 1997.
362.Kostenuik PJ, Harris J, Halloran BP, Turner RT, Morey-Holton ER, and Bikle DD. Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I. J Bone Miner Res 14: 21-31, 1999.
363.Kosugi K, Nakaya M, Takeuchi S, and Yamashita H. Influence to organs by ten weeks tail suspension. Physiologist 36: S147-148, 1993.
364.Krasnov IB. Gravitational neuromorphology. Adv Space Biol Med 4: 85-110, 1994.
365.Krasnov IB, Poliakov IV, and Drobyshev VI. [Effect of space flight and head-down position on motoneuron- glia-capillary system of the rat bone marrow]. Aviakosm Ekolog Med 27: 38-42, 1993.
366.Krippendorf BB, and Riley DA. Distinguishing unloading- versus reloading-induced changes in rat soleus muscle. Muscle Nerve 16: 99-108, 1993.
367.Krippendorf BB, and Riley DA. Temporal changes in sarcomere lesions of rat adductor longus muscles during hindlimb reloading. Anat Rec 238: 304-310, 1994.
368.Ku Z, Thomason DB, Jaspers SR, Fagan JM, Satarug S, Cook PH, and Tischler ME. Soleus muscle nascent polypeptide chain elongation slows protein synthesis rate during non-weight-bearing activity. Am J Physiol 267: C115-126, 1994.
369.Ku Z, Yang J, Menon V, and Thomason DB. Decreased polysomal HSP-70 may slow polypeptide elongation during skeletal muscle atrophy. Am J Physiol 268: C1369-1374, 1995.
370.Kunishima T. [Ultrastructural and biochemical enzymatic properties of right ventricular muscles during hindlimb suspension in rats]. Nippon Seirigaku Zasshi 55: 153-164, 1993.
371.Kurokouchi K, Ito T, Ohmori S, Kanda K, Murata Y, and Seo H. Changes in the markers of bone metabolism following skeletal unloading. Environ Med 39: 21-24, 1995.
372.Kuznetsov SL, and Talis VL. [Problem of modeling the physiologic effects of weightlessness by the method of "antiorthostatic suspension" of small laboratory animals]. Kosm Biol Aviakosm Med 23: 74-76, 1989.
373.Kuznetsov SL, and Talis VL. [State of skeletal muscle fibers in rats during physical exercise after anti-orthostatic tail suspension in modeling the weightlessness]. Kosm Biol Aviakosm Med 24: 31-34, 1990.
374.Lacaille M, Mercier C, and Simard C. Effects of electrical stimulation on the activity of hexokinase in the medial gastrocnemius muscle of aged rats after hindlimb suspension. Comp Biochem Physiol A 96: 469-471, 1990.
375.Laib A, Barou O, Vico L, Lafage-Proust MH, Alexandre C, and Rugsegger P. 3D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis. Med Biol Eng Comput 38: 326-332, 2000.
376.Lange RD, Jones JB, and Johnson PC, Jr. Comparative aspects of hematological responses in animal and human models in simulations of weightlessness and space flight. Physiologist 30: S113-116, 1987.
377.Langfort J, Zernicka E, Mayet-Sornay MH, Dubaniewicz A, and Desplanches D. Effects of acute and chronic hindlimb suspension on sensitivity and responsiveness to insulin in the rat soleus muscle. Biochem Cell Biol 75: 41-44, 1997.
378.Langlet C, Canu MH, and Falempin M. Short-term reorganization of the rat somatosensory cortex following hypodynamia-hypokinesia. Neurosci Lett 266: 145-148, 1999.
379.Lavrova EA, Natochin IV, Serova LV, and Snetkova EV. [Body fluid and electrolyte content in rat tissues after space flight in the "Space-2044" spacecraft]. Aviakosm Ekolog Med 27: 43-47, 1993.
380.LeBlanc A, Evans H, Schonfeld E, Ford J, Marsh C, Schneider V, and Johnson P. Relaxation times of normal and atrophied muscle. Med Phys 13: 514-517, 1986.
381.LeBlanc A, Marsh C, Evans H, Johnson P, Schneider V, and Jhingran S. Bone and muscle atrophy with suspension of the rat. J Appl Physiol 58: 1669-1675, 1985.
382.Leterme D, and Casasnovas B. Adaptation of rat lateral gastrocnemius muscle motor units during hindlimb unloading. Eur J Appl Physiol Occup Physiol 79: 312-317, 1999.
383.Leterme D, Cordonnier C, Mounier Y, and Falempin M. Influence of chronic stretching upon rat soleus muscle during non-weight-bearing conditions. Pflugers Arch 429: 274-279, 1994.
384.Leterme D, and Falempin M. Compensatory effects of chronic electrostimulation on unweighted rat soleus muscle. Pflugers Arch 426: 155-160, 1994.
385.Leterme D, and Falempin M. Contractile properties of rat soleus motor units following 14 days of hindlimb unloading. Pflugers Arch 432: 313-319, 1996.
386.Leterme D, and Falempin M. EMG activity of three rat hindlimb muscles during microgravity and hypergravity phase of parabolic flight. Aviat Space Environ Med 69: 1065-1070, 1998.
387.Leterme D, Falempin M, and Mounier Y. Preliminary results of the influence of direct stimulation on the mechanical properties of the soleus muscle of rats during hindlimb suspension. Physiologist 34: S179-180, 1991.
388.Linderman JK, Gosselink KL, Booth FW, Mukku VR, and Grindeland RE. Resistance exercise and growth hormone as countermeasures for skeletal muscle atrophy in hindlimb-suspended rats. Am J Physiol 267: R365-371, 1994.
389.Linderman JK, Talmadge RJ, Gosselink KL, Tri PN, Roy RR, and Grindeland RE. Synergistic ablation does not affect atrophy or altered myosin heavy chain expression in the non-weight bearing soleus muscle. Life Sci 59: 789-795, 1996.
390.Linderman JK, Whittall JB, Gosselink KL, Wang TJ, Mukku VR, Booth FW, and Grindeland RE. Stimulation of myofibrillar protein synthesis in hindlimb suspended rats by resistance exercise and growth hormone. Life Sci 57: 755-762, 1995.
391.Liu C, Yu Z-B, Zhang L-F, and Ni H-Y. Heat shock protein 70 expression in myocardium is blunted with simulated weightlessness. J Gravit Physiol 7: PP149-150, 2000.
392.Liu C, Zhang LF, Yu ZB, and Ni HY. [Heat stress-induced HSP70 expression in heart and vessels of simulated weightless rats]. Sheng Li Xue Bao 53: 123-127, 2001.
393.Loginov VA, Timonin IM, Minchenko BI, and Klimovitskii VI. [The permeability of rat erythrocyte membranes for sodium and potassium ions during exposure to pulsed electromagnetic field under head-down-tilt hypokinesia]. Aviakosm Ekolog Med 26: 71-75, 1992.
394.Looft-Wilson RC, and Gisolfi CV. Rat small mesenteric artery function after hindlimb suspension. J Appl Physiol 88: 1199-1206, 2000.
395.Loomer PM. The impact of microgravity on bone metabolism in vitro and in vivo. Crit Rev Oral Biol Med 12: 252-261, 2001.
396.Loughna P, Goldspink G, and Goldspink DF. Effect of inactivity and passive stretch on protein turnover in phasic and postural rat muscles. J Appl Physiol 61: 173-179, 1986.
397.Loughna PT, Goldspink DF, and Goldspink G. Effects of hypokinesia and hypodynamia upon protein turnover in hindlimb muscles of the rat. Aviat Space Environ Med 58: A133-138, 1987.
398.Louisy F, Tran CC, Resch G, Lemarquer-Domagala F, Finet M, Si S, Wang T, and Yang G. [Effect of upright tilt on venous hemodynamics in rat after three-week tail suspension]
[Study on mechanisms of T lymphocyte function changes in mice under simulated weightlessness in terms of IL-2 and Bcl-2 gene transcription]. Trav Sci Cherch Serv Sante Armees 20: 173-174, 1999.
399.Louisy F, Tran CC, Resch G, Luce P, Lemarquer F, and Finet M. The venous tone is not altered after three-week tail suspension in rats. J Gravit Physiol 5: 47-48, 1998.
400.Lutz J, Chen F, and Kasper CE. Hypokinesia-induced negative net calcium balance reversed by weight-bearing exercise. Aviat Space Environ Med 58: 308-314, 1987.
401.Ma J, Zhang L, and Yang T. Alteration of vasoreactivity of mesenteric arteries in rats after two-week simulated weightlessness. Space Med Med Eng (Beijing) 11: 79-82, 1998.
402.Ma J, Zhang L-N, and Zhang L-F. Vsoconstrictor responsiveness of hind body vascular beds is diminished in tail-suspended rats. J Gravit Physiol 7: P153-154, 2000.
403.Ma J, Zhang LF, and Yu ZB. Effects of 14-day tail suspension on vasoreactivity of arteries from different parts of the body in rats. J Gravit Physiol 3: 9-10, 1996.
404.Ma J, Zhang LF, Yu ZB, and Zhang LN. Time course and reversibility of arterial vasoreactivity changes in simulated microgravity rats. J Gravit Physiol 4: 45-46, 1997.
405.Ma J, Zhang LN, Zhang LF, and Yang TD. [Effects of simulated weightlessness on vasoreactivity of hindlimb arterial bed in rats]. Space Med Med Eng (Beijing) 12: 254-257, 1999.
406.Ma YL, Sun YZ, and Yang HH. [Protective effect of RenShen compound and DanHuang compound on muscle atrophy in suspended rats]. Space Med Med Eng (Beijing) 12: 281-283, 1999.
407.Machkov VV, Tarasova OS, Timin EN, Rodionov IM, and Vinogradova OL. [Attenuation of the efficacy of vasoconstrictive effects in rats after a 3-week suspension]. Aviakosm Ekolog Med 31: 43-47, 1997.
408.Macho L, Fickova M, Svabova E, Zorad S, Serova L, and Popova I. Changes of insulin in plasma and receptor for insulin in various tissues after the exposure of rats to space flights and hypokinesia. J Gravit Physiol 1: 23-24, 1994.
409.Machwate M, Zerath E, Holy X, Hott M, Godet D, Lomri A, and Marie PJ. Systemic administration of transforming growth factor-beta 2 prevents the impaired bone formation and osteopenia induced by unloading in rats. J Clin Invest 96: 1245-1253, 1995.
410.Machwate M, Zerath E, Holy X, Hott M, Modrowski D, Malouvier A, and Marie PJ. Skeletal unloading in rat decreases proliferation of rat bone and marrow-derived osteoblastic cells. Am J Physiol 264: E790-799, 1993.
411.Machwate M, Zerath E, Holy X, Pastoureau P, and Marie PJ. Insulin-like growth factor-I increases trabecular bone formation and osteoblastic cell proliferation in unloaded rats. Endocrinology 134: 1031-1038, 1994.
412.Maignan E, Martel E, Safar M, and Cuche J-L. Norepinephrine kinetics in the rat with tail-suspension-induced central hypervolemia as a model of cardiovascular deconditioning. J Gravit Physiol 7: P141-142, 2000.
413.Mao QW, Zhang LF, and Ma J. Observations on arteriolar network structure in soleus of tail-suspended rats. J Gravit Physiol 4: 129-130, 1997.
414.Mao QW, Zhang LF, Zhang LN, and Ma J. [Ultrastructural changes of arterial wall from different body parts of rats during simulated weightlessness]. Space Med Med Eng (Beijing) 12: 249-253, 1999.
415.Markin AA, Zhuravleva OA, and Balashov OI. [Lipid peroxidation and activity of diagnostically important blood enzymes in rats during 35 days head-down suspension]. Aviakosm Ekolog Med 34: 31-37, 2000.
416.Marsh DR, Campbell CB, and Spriet LL. Effect of hindlimb unweighting on anaerobic metabolism in rat skeletal muscle. J Appl Physiol 72: 1304-1310, 1992.
417.Martel E, Champeroux P, Lacolley P, Richard S, Safar M, and Cuche JL. Central hypervolemia in the conscious rat: a model of cardiovascular deconditioning. J Appl Physiol 80: 1390-1396, 1996.
418.Martel E, Lacolley P, Champeroux P, Brisac AM, Laurent S, Cuche JL, and Safar ME. Early disturbance of baroreflex control of heart rate after tail suspension in conscious rats. Am J Physiol 267: H2407-2412, 1994.
419.Martel E, Ponchon P, Champeroux P, Elghozi JL, Renaud de la Faverie JF, Dabire H, Pannier B, Richard S, Safar M, and Cuche JL. Mechanisms of the cardiovascular deconditioning induced by tail suspension in the rat. Am J Physiol 274: H1667-1673, 1998.
420.Martin RB. Effects of simulated weightlessness on bone properties in rats. J Biomech 23: 1021-1029, 1990.
421.Martin TP, Edgerton VR, and Grindeland RE. Influence of spaceflight on rat skeletal muscle. J Appl Physiol 65: 2318-2325, 1988.
422.Masseguin C, Corcoran M, Carcenac C, Daunton NG, Guell A, Verkman AS, and Gabrion J. Altered gravity downregulates aquaporin-1 protein expression in choroid plexus. J Appl Physiol 88: 843-850, 2000.
423.Matsumoto T, Nakayama K, Kodama Y, Fuse H, Nakamura T, and Fukumoto S. Effect of mechanical unloading and reloading on periosteal bone formation and gene expression in tail-suspended rapidly growing rats. Bone 22: 89S-93S, 1998.
424.Matsuura T, Ikata T, Takata S, Kashiwaguchi S, Niwa M, Sogabe T, and Koga K. Effect of weight bearing on recovery from nerve injury in skeletal muscle. J Appl Physiol 91: 2334-2341, 2001.
425.Maurel D, Ixart G, Barbanel G, Mekaouche M, and Assenmacher I. Effects of acute tilt from orthostatic to head-down antiorthostatic restraint and of sustained restraint on the intra-cerebroventricular pressure in rats. Brain Res 736: 165-173, 1996.
426.Mayet-Sornay MH, and Desplanches D. Rat muscle plasticity in response to simulated or real microgravity. J Gravit Physiol 3: 50-53, 1996.
427.Maynard JA. The effects of space flight on the composition of the intervertebral disc. Iowa Orthop J 14: 125-133, 1994.
428.McCarthy JJ, Fox AM, Tsika GL, Gao L, and Tsika RW. beta-MHC transgene expression in suspended and mechanically overloaded/suspended soleus muscle of transgenic mice. Am J Physiol 272: R1552-1561, 1997.
429.McCarthy JJ, Vyas DR, Tsika GL, and Tsika RW. Segregated regulatory elements direct beta-myosin heavy chain expression in response to altered muscle activity. J Biol Chem 274: 14270-14279, 1999.
430.McCombs GB, Ott CE, and Jackson BA. Effects of thoracic volume expansion on cardiorenal function in the conscious rat. Aviat Space Environ Med 67: 1086-1091, 1996.
431.McCurdy MR, Colleran PN, Muller-Delp J, and Delp MD. Effects of fiber composition and hindlimb unloading on the vasodilator properties of skeletal muscle arterioles. J Appl Physiol 89: 398-405, 2000.
432.McDermott JC, Elder GC, and Bonen A. Non-exercising muscle metabolism during exercise. Pflugers Arch 418: 301-307, 1991.
433.McDonald KS, Blaser CA, and Fitts RH. Force-velocity and power characteristics of rat soleus muscle fibers after hindlimb suspension. J Appl Physiol 77: 1609-1616, 1994.
434.McDonald KS, Delp MD, and Fitts RH. Effect of hindlimb unweighting on tissue blood flow in the rat. J Appl Physiol 72: 2210-2218, 1992.
435.McDonald KS, Delp MD, and Fitts RH. Fatigability and blood flow in the rat gastrocnemius-plantaris-soleus after hindlimb suspension. J Appl Physiol 73: 1135-1140, 1992.
436.McDonald KS, and Fitts RH. Effect of hindlimb unloading on rat soleus fiber force, stiffness, and calcium sensitivity. J Appl Physiol 79: 1796-1802, 1995.
437.McDonald KS, and Fitts RH. Effect of hindlimb unweighting on single soleus fiber maximal shortening velocity and ATPase activity. J Appl Physiol 74: 2949-2957, 1993.
438.McNulty AL, Otto AJ, Kasper CE, and Thomas DP. Effect of recovery mode following hind-limb suspension on soleus muscle composition in the rat. Int J Sports Med 13: 6-14, 1992.
439.Mednieks MI, Popova I, and Grindeland RE. Photoaffinity labeling of regulatory subunits of protein kinase A in cardiac cell fractions of rats. J Appl Physiol 73: 101S-106S, 1992.
440.Medvedev OS, Bychkova EI, Zaretskii DV, Murashev AN, Zaretskaia MV, and Seleznev DM. [Changes in the NO-dependent regulation of the local cerebral blood flow in rats during adaptation to the conditions of simulated weightlessness]. Aviakosm Ekolog Med 33: 42-46, 1999.
441.Medvedev OS, Murashev AN, Byckova EI, Zaretskii DV, and Shibaev AN. [Effect of antiorthostatic pre-training on transcapillary turnover of fluids in extra- and intracranial vessels of rats in antiorthostatic hypokinesia]. Aviakosm Ekolog Med 32: 17-21, 1998.
442.Megeney LA, Elder GC, Tan MH, and Bonen A. Increased glucose transport in nonexercising muscle. Am J Physiol 262: E20-26, 1992.
443.Menon V, and Thomason DB. Head-down tilt increases rat cardiac muscle eIF-2 alpha phosphorylation. Am J Physiol 269: C802-804, 1995.
444.Menon V, Yang J, Ku Z, and Thomason DB. Decrease in heart peptide initiation during head-down tilt may be modulated by HSP-70. Am J Physiol 268: C1375-1380, 1995.
445.Mercier C, Jobin J, Lepine C, and Simard C. Effects of hindlimb suspension on contractile properties of young and old rat muscles and the impact of electrical stimulation on the recovery process. Mech Ageing Dev 106: 305-320, 1999.
446.Mercier C, Lacaille M, and Simard C. Influence of electrical stimulation on enzymatic activity of old rat muscles during hindlimb suspension. Mech Ageing Dev 68: 117-124, 1993.
447.Merrill AH, Jr, Wang E, LaRocque R, Mullins RE, Morgan ET, Hargrove JL, Bonkovsky HL, and Popova IA. Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS 2044. J Appl Physiol 73: 142S-147S, 1992.
448.Merrill AH, Jr, Wang E, Mullins RE, Grindeland RE, and Popova IA. Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044. J Appl Physiol 73: 132S-135S, 1992.
449.Michel RN, and Gardiner PF. To what extent is hindlimb suspension a model of disuse? Muscle Nerve 13: 646-653, 1990.
450.Michel RN, Olha AE, and Gardiner PF. Influence of weight bearing on the adaptations of rat plantaris to ablation of its synergists. J Appl Physiol 67: 636-642, 1989.
451.Miller ES, Bates RA, Koebel DA, and Sonnenfeld G. Antiorthostatic suspension stimulates profiles of macrophage activation in mice. Neuroimmunomodulation 6: 160-167, 1999.
452.Miller ES, Koebel DA, Davis SA, Klein JB, McLeish KR, Goldwater D, and Sonnenfeld G. Influence of suspension on the oxidative burst by rat neutrophils. J Appl Physiol 76: 387-390, 1994.
453.Miller ES, and Sonnenfeld G. Influence of antiorthostatic suspension on resistance to murine Listeria monocytogenes infection. J Leukoc Biol 55: 371-378, 1994.
454.Miller ES, and Sonnenfeld G. Influence of suspension on the expression of protective immunological memory to murine Listeria monocytogenes infection. J Leukoc Biol 54: 578-583, 1993.
455.Miller TA, Lesniewski LA, Muller-Delp JM, Majors AK, Scalise D, and Delp MD. Hindlimb unloading induces a collagen isoform shift in the soleus muscle of the rat. Am J Physiol Regul Integr Comp Physiol 281: R1710-1717, 2001.
456.Mitchell ME, Stern LS, Shah N, and Ostrum R. Effect of flurbiprofen on hind-limb suspension-induced bone loss. Aviat Space Environ Med 72: 790-793, 2001.
457.Moffitt JA, Foley CM, Schadt JC, Laughlin MH, and Hasser EM. Attenuated baroreflex control of sympathetic nerve activity after cardiovascular deconditioning in rats. Am J Physiol 274: R1397-1405, 1998.
458.Moffitt JA, Schadt JC, and Hasser EM. Altered central nervous system processing of baroreceptor input following hindlimb unloading in rats. Am J Physiol 277: H2272-2279, 1999.
459.Mokhtarian A, Lefaucheur JP, Even PC, and Sebille A. Hindlimb immobilization applied to 21-day-old mdx mice prevents the occurrence of muscle degeneration. J Appl Physiol 86: 924-931, 1999.
460.Mondon CE, Rodnick KJ, Dolkas CB, Azhar S, and Reaven GM. Alterations in glucose and protein metabolism in animals subjected to simulated microgravity. Adv Space Res 12: 169-177, 1992.
461.Montufar-Solis D, Duke PJ, and Durnova G. Spaceflight and age affect tibial epiphyseal growth plate histomorphometry. J Appl Physiol 73: 19S-25S, 1992.
462.Morel JL, Boittin FX, Halet G, Arnaudeau S, Mironneau C, and Mironneau J. Effect of a 14-day hindlimb suspension on cytosolic Ca2+ concentration in rat portal vein myocytes. Am J Physiol 273: H2867-2875, 1997.
463.Morey ER. Spaceflight and bone turnover: correlation with a new rat model of weightlessness. BioScience 29: 168-172, 1979.
464.Morey ER, Sabelman EE, Turner RT, and Baylink DJ. A new rat model simulating some aspects of space flight. Physiologist 22: S23-24, 1979.
465.Morey-Holton E, and Wronski TJ. Animal models for simulating weightlessness. Physiologist 24: S45-S46, 1981.
466.Morey-Holton ER, Bomalaski MD, Enayatii-Gordon E, Gonsalves MR, and Wronski TJ. Is suppression of bone formation during simulated weightlessness related to glucocorticoid levels? 25 6 Suppl: S145-S146, 1982.
467.Morey-Holton ER, and Globus RK. Hindlimb unloading of growing rats: a model for predicting skeletal changes during space flight. Bone 22: 83S-88S, 1998.
468.Morrison PR, Montgomery JA, Wong TS, and Booth FW. Cytochrome c protein-synthesis rates and mRNA contents during atrophy and recovery in skeletal muscle. Biochem J 241: 257-263, 1987.
469.Morrison PR, Muller GW, and Booth FW. Actin synthesis rate and mRNA level increase during early recovery of atrophied muscle. Am J Physiol 253: C205-209, 1987.
470.Morukov BV, Orlov OI, Belakovskii MS, Kazeikin VS, Zaichik VE, Shvets VN, and Tumanova, II. [Effect of simulated weightlessness on calcium metabolism and the condition of bone tissue in experimental animals]. Kosm Biol Aviakosm Med 24: 31-34, 1990.
471.Mounier Y, Picquet F, and Stevens L. Postnatal muscle development in unloading conditions. Int J Sports Med 18: S298-299, 1997.
472.Mozdziak PE, Greaser ML, and Schultz E. Myogenin, MyoD, and myosin heavy chain isoform expression following hindlimb suspension. Aviat Space Environ Med 70: 511-516, 1999.
473.Mozdziak PE, Pulvermacher PM, and Schultz E. Muscle regeneration during hindlimb unloading results in a reduction in muscle size after reloading. J Appl Physiol 91: 183-190, 2001.
474.Mozdziak PE, Pulvermacher PM, and Schultz E. Unloading of juvenile muscle results in a reduced muscle size 9 wk after reloading. J Appl Physiol 88: 158-164, 2000.
475.Mozdziak PE, Truong Q, Macius A, and Schultz E. Hindlimb suspension reduces muscle regeneration. Eur J Appl Physiol Occup Physiol 78: 136-140, 1998.
476.Munoz KA, Aannestad A, Tischler ME, and Henriksen EJ. Skeletal muscle protein content and synthesis after voluntary running and subsequent unweighting. Metabolism 43: 994-999, 1994.
477.Munoz KA, Satarug S, and Tischler ME. Time course of the response of myofibrillar and sarcoplasmic protein metabolism to unweighting of the soleus muscle. Metabolism 42: 1006-1012, 1993.
478.Munoz KA, and Tischler ME. The effect of a space food bar diet on body and muscle mass in normal and hind-limb suspended rats. Aviat Space Environ Med 62: 875-878, 1991.
479.Musacchia XJ. An assessment of suspension systems: models that reproduce responses to weightlessness. Physiologist 35: S92-95, 1992.
480.Musacchia XJ. The use of suspension models and comparison with true weightlessness: "a resume". Physiologist 28: S237-240, 1985.
481.Musacchia XJ, and Deavers DR. A new rat model for studies of hypokinesia and antiorthostasis. Physiologist 23: S91-92, 1980.
482.Musacchia XJ, Deavers DR, and Meininger GA. Fluid/electrolyte balance and cardiovascular responses: head-down tilted rats. Physiologist 33: S46-47, 1990.
483.Musacchia XJ, Deavers DR, Meininger GA, and Davis TP. A model for hypokinesia: effects on muscle atrophy in the rat. J Appl Physiol 48: 479-486, 1980.
484.Musacchia XJ, and Fagette S. Weightlessness simulations for cardiovascular and muscle systems: validity of rat models. J Gravit Physiol 4: 49-59, 1997.
485.Musacchia XJ, and Steffen JM. Cardiovascular and hormonal (aldosterone) responses in a rat model which mimics responses to weightlessness. Physiologist 27: S41-42, 1984.
486.Musacchia XJ, and Steffen JM. Effect of suspension hypokinesia/hypodynamia on glucocorticoid receptor levels in rat hindlimb muscles. Physiologist 25: S151-152, 1982.
487.Musacchia XJ, and Steffen JM. Short term (1 and 3 day) cardiovascular adjustments to suspension antioorthostasis in rats. Physiologist 25: S163-164, 1982.
488.Musacchia XJ, and Steffen JM. The validity of an animal model for experiments related to weightlessness. Physiologist 26: S137-138, 1983.
489.Musacchia XJ, Steffen JM, and Deaver DR. Suspension restraint: induced hypokinesia and antiorthostasis as a simulation of weightlessness. Physiologist 24: S21-S22, 1981.
490.Musacchia XJ, Steffen JM, and Deavers DR. Rat hindlimb muscle responses to suspension hypokinesia/hypodynamia. Aviat Space Environ Med 54: 1015-1020, 1983.
491.Musacchia XJ, Steffen JM, and Dombrowski J. Rat cardiovascular responses to whole body suspension: head-down and non-head-down tilt. J Appl Physiol 73: 1504-1509, 1992.
492.Musacchia XJ, Steffen JM, and Fell RD. Disuse atrophy of skeletal muscle: animal models. Exerc Sport Sci Rev 16: 61-87, 1988.
493.Musacchia XJ, Steffen JM, Fell RD, and Dombrowski J. Physiological comparison of rat muscle in body suspension and weightlessness. Physiologist 30: S102-105, 1987.
494.Musacchia XJ, Steffen JM, Fell RD, and Dombrowski MJ. Comparative morphometry of fibers and capillaries in soleus following weightlessness (SL-3) and suspension. Physiologist 31: S28-29, 1988.
495.Musacchia XJ, Steffen JM, Fell RD, and Dombrowski MJ. Skeletal muscle response to spaceflight, whole body suspension, and recovery in rats. J Appl Physiol 69: 2248-2253, 1990.
496.Musacchia XJ, Steffen JM, Fell RD, Dombrowski MJ, Oganov VW, and Ilyina-Kakueva EI. Skeletal muscle atrophy in response to 14 days of weightlessness: vastus medialis. J Appl Physiol 73: 44S-50S, 1992.
497.Musacchia XJ, Steffen JM, and Stepke B. Variations in recovery and readaptation to load bearing conditions after space flight and whole body suspension in the rat. Physiologist 34: S170-171, 1991.
498.Naito H, Powers SK, Demirel HA, Sugiura T, Dodd SL, and Aoki J. Heat stress attenuates skeletal muscle atrophy in hindlimb-unweighted rats. J Appl Physiol 88: 359-363, 2000.
499.Nakano H, and Katsuta S. Non-weight-bearing condition arrests the morphological and metabolic changes of rat soleus motoneurons during postnatal growth. Neurosci Lett 290: 145-148, 2000.
500.Nakaya M, Ikawa S, Kosugi K, and Takeuchi S. Sex differences in blood constituents of rats following tail suspension. Physiologist 33: S110-111, 1990.
501.Nakaya M, Kosugi K, and Takeuchi S. Changes in blood biochemical parameters in tail-suspended rats. J Gravit Physiol 2: 119-120, 1995.
502.Nakaya M, Kosugi K, and Takeuchi S. Effect of long-term hindlimb suspension on blood components. Physiologist 34: S92-93, 1991.
503.Nakaya M, Kosugi K, and Takeuchi S. Effects of exercise on rats subjected to tail suspension. J Gravit Physiol 1: 67-68, 1994.
504.Nakaya M, Kosugi K, and Takeuchi S. Relationship between hind-limb muscle atrophy and serum enzymes in tail suspended rats. Physiologist 36: S149-150, 1993.
505.Nash PV, Bour BA, and Mastro AM. Effect of hindlimb suspension simulation of microgravity on in vitro immunological responses. Exp Cell Res 195: 353-360, 1991.
506.Nash PV, Konstantinova IV, Fuchs BB, Rakhmilevich AL, Lesnyak AT, and Mastro AM. Effect of spaceflight on lymphocyte proliferation and interleukin-2 production. J Appl Physiol 73: 186S-190S, 1992.
507.Nasledov GA, Arutyunyan RS, Nemirovskaya TL, Shenkman BS, and Kozlovskya IB. Contractile properties of rat skeletal muscles after hindlimb unloading and ß-GPA administration. J Gravit Physiol 3: 11-12, 1996.
508.Nasledov GA, Nemirovskaia TL, Arutiunian RS, Feebeck D, Shein VI, and Shenkman BS. [Beta-guanidinopropionic acid prevents decrease in muscle performance and reduction in mitochondrial enzymes activation under gravitation unloading in rats]. Dokl Akad Nauk 363: 126-129, 1998.
509.Nathan JM, Bradshaw BA, Bartoletti N, and Witten ML. Non-invasive measurement of organ density in a rat simulated microgravity model. Aviat Space Environ Med 71: 894-898, 2000.
510.Navidi M, Wolinsky I, Fung P, and Arnaud SB. Effect of excess dietary salt on calcium metabolism and bone mineral in a spaceflight rat model. J Appl Physiol 78: 70-75, 1995.
511.Nemirovskaya T, Shenkman B, Nasledov G, and Arutyunyan R. Physical performance and skeletal muscle characteristics after 2-week hind-limb unweighting. J Gravit Physiol 4: 135-136, 1997.
512.Nemirovskaya TL, and Shenkman BS. Influence of single hindlimb support on fiber characteristics of unloaded skeletal muscle. J Gravit Physiol 6: P151-152, 1999.
513.Nemirovskaya TL, Shenkman BS, Matsievskii DD, Bychkova E, Maevskii EI, and Grishina E. Decreased concentration of high-energy phosphates prevents a decrease in redox potential of skeletal muscles under gravitational unloading. Dokl Biol Sci 370: 10-13, 2000.
514.Nemirovskaya TL, Shenkman BS, Mayevsky EI, and Grishina E. What is the trigger mechanism for changes of the oxidative potential in skeletal muscle? J Gravit Physiol 5: 79-80, 1998.
515.Nomura T, Kawano F, Sato Y, Ishihara A, and Ohira Y. Effects of 9 weeks hindlimb suspension on neuromuscular activity patterns in rat. J Gravit Physiol 7: P113-114, 2000.
516.Nonaka I, Miyazawa M, Sukegawa T, Yonemoto K, and Kato T. Muscle fiber atrophy and degeneration induced by experimental immobility and hindlimb suspension. Int J Sports Med 18: S292-294, 1997.
517.Norman TL, Bradley-Popovich G, Clovis N, Cutlip RG, and Bryner RW. Aerobic exercise as a countermeasure for microgravity-induced bone loss and muscle atrophy in a rat hindlimb suspension model. Aviat Space Environ Med 71: 593-598, 2000.
518.Noskovic P, Ahlers I, and Racek L. New modification of suspension hypokinesia in rats. Physiol Bohemoslov 39: 471-474, 1990.
519.Novikov VE, and Ilyin EA. Age-related reactions of rat bones to their unloading. Aviat Space Environ Med 52: 551-553, 1981.
520.O'Connor KM. Unweighting accelerates tidemark advancement in articular cartilage at the knee joint of rats. J Bone Miner Res 12: 580-589, 1997.
521.Oganov VS. Functional plasticity of skeletal muscles of mammals in space flight. Mater Med Pol 22: 251-254, 1990.
522.Oganov VS, Murashko LM, Kabitskaya OE, Szilagyi T, and Rapcsak M. Physiological characteristics of rat skeletal muscles after the flight on board "Cosmos-2044" biosatellite. Physiologist 34: S174-176, 1991.
523.Oganov VS, Skuratova SA, and Murashko LM. [Contractile properties of skeletal muscles of rats after flight on "Kosmos-1887"]. Kosm Biol Aviakosm Med 25: 44-47, 1991.
524.Oganov VS, Skuratova SA, Potapov AN, and Shirvinskaya MA. Physiological mechanisms of adaptation of rat skeletal muscles to weightlessness and similar functional requirements. Physiologist 23: S16-21, 1980.
525.Ogawa S, Yamazaki S, Okamoto H, Fukuda S, Iemori S, and Taguchi S. [Effect of weightlessness simulation on skeletal muscle histochemistry and bone metabolism of spontaneously hypertensive rats]. Nippon Seirigaku Zasshi 57: 419-426, 1995.
526.Ohira Y, Jiang B, Roy RR, Oganov V, Ilyina-Kakueva E, Marini JF, and Edgerton VR. Rat soleus muscle fiber responses to 14 days of spaceflight and hindlimb suspension. J Appl Physiol 73: 51S-57S, 1992.
527.Ohira Y, Saito K, Wakatsuki T, Yasui W, Suetsugu T, Nakamura K, Tanaka H, and Asakura T. Responses of beta-adrenoceptor in rat soleus to phosphorus compound levels and/or unloading. Am J Physiol 266: C1257-1262, 1994.
528.Ohira Y, Tanaka T, Segawa M, Kizaki T, Ookawara T, Oh-ishi S, and Ohno H. Unloading does not increase brown-adipose-tissue activity in rat pups. Res Commun Mol Pathol Pharmacol 104: 193-204, 1999.
529.Ohira Y, Tanaka T, Yoshinaga T, Kawano F, Nomura T, Nonaka I, Allen DL, Roy RR, and Edgerton VR. Dependence of normal development of skeletal muscle in neonatal rats on load bearing. J Gravit Physiol 7: P27-30, 2000.
530.Ohira Y, Tanaka T, Yoshinaga T, Kawano F, Nomura T, Nonaka I, Allen DL, Roy RR, and Edgerton VR. Ontogenetic, gravity-dependent development of rat soleus muscle. Am J Physiol Cell Physiol 280: C1008-1016, 2001.
531.Ohira Y, Tanaka T, Yoshinaga T, Ohara M, and Edgerton VR. Role of gravitational loading on the development of soleus muscle in rats. Int J Sports Med 18: S295-296, 1997.
532.Ohira Y, Yasui W, Kariya F, Wakatsuki T, Nakamura K, Asakura T, and Edgerton VR. Metabolic adaptation of skeletal muscles to gravitational unloading. Acta Astronaut 33: 113-117, 1994.
533.Ohira Y, Yasui W, Roy RR, and Edgerton VR. Effects of muscle length on the response to unloading. Acta Anat (Basel) 159: 90-98, 1997.
534.Oishi Y. Relationship between myosin heavy chain IId isoform and fibre types in soleus muscle of the rat after hindlimb suspension. Eur J Appl Physiol Occup Physiol 66: 451-454, 1993.
535.Oishi Y, Ishihara A, Nagano K, Iijima N, Ohira A, Miyamoto E, and Ihata Y. [Change in expression pattern of myosin heavy chain isoforms in soleus muscle of the rats after hindlimb suspension]. Nippon Seirigaku Zasshi 61: 377-382, 1999.
536.Oishi Y, Ishihara A, Talmadge RJ, Ohira Y, Taniguchi K, Matsumoto H, Roy RR, and Edgerton VR. Expression of heat shock protein 72 in atrophied rat skeletal muscles. Acta Physiol Scand 172: 123-130, 2001.
537.Oishi Y, Ishihara A, Yamamoto H, and Miyamoto E. Hindlimb suspension induces the expression of multiple myosin heavy chain isoforms in single fibres of the rat soleus muscle. Acta Physiol Scand 162: 127-134, 1998.
538.Oishi Y, Yamamoto H, and Miyamoto E. Changes in fibre-type composition and myosin heavy-chain IId isoform in rat soleus muscle during recovery period after hindlimb suspension. Eur J Appl Physiol Occup Physiol 68: 102-106, 1994.
539.Oomura Y, and Katafuchi T. Neurophysiological responses in suspended animal models. Physiologist 30: S106-108, 1987.
540.Orlov OI, Shashkov VS, and Grigor'ev AI. [The effect of diphosphonates on the metabolism of calcium, its regulation and the state of the bone tissue in the modelling of the physiological effects of weightlessness]. Eksp Klin Farmakol 55: 61-65, 1992.
541.Ortiz RM, Wang TJ, and Wade CE. Influence of centrifugation and hindlimb suspension on testosterone and corticosterone excretion in rats. Aviat Space Environ Med 70: 499-504, 1999.
542.Osadchii LI, Balueva TV, and Sergeev IV. [Effects of the tone of arterial vessels on the antiorthostatic response of hemodynamics]. Aviakosm Ekolog Med 31: 20-24, 1997.
543.Osako T, Ohira Y, Ito G, Iwashita Y, Norikura T, and Maki E. Structure and mineral content in weight-bearing bones following hindlimb suspension in young rats. Jpn J Physiol 41: 923-932, 1991.
544.Overton JM, and Tipton CM. Effect of hindlimb suspension on cardiovascular responses to sympathomimetics and lower body negative pressure. J Appl Physiol 68: 355-362, 1990.
545.Overton JM, Woodman CR, and Tipton CM. Effect of hindlimb suspension on VO2 max and regional blood flow responses to exercise. J Appl Physiol 66: 653-659, 1989.
546.Padilla MT, Balagtas MP, Braun EJ, Vargas J, Hall JN, and Witten ML. Changes in radioactive tracer distribution in rats after 24 hours of 45 degrees hind limb unweighting. Aviat Space Environ Med 68: 726-731, 1997.
547.Pamnani MB, Chen S, Haddy FJ, Yuan C, and Mo Z. Role of digitalis-like substance in the hypertension of streptozotocin-induced diabetes and simulated weightlessness in rats. Clin Exp Hypertens 20: 509-521, 1998.
548.Pamnani MB, Mo Z, Chen S, Bryant HJ, White RJ, and Haddy FJ. Effects of head down tilt on hemodynamics, fluid volumes, and plasma Na-K pump inhibitor in rats. Aviat Space Environ Med 67: 928-934, 1996.
549.Park E, and Schultz E. A simple hindlimb suspension apparatus. Aviat Space Environ Med 64: 401-404, 1993.
550.Park SC, Kim WH, Lee MC, Seong SC, Song KY, and Choe MA. Modulation of transglutaminase expression in rat skeletal muscle by induction of atrophy and endurance training. J Korean Med Sci 9: 490-496, 1994.
551.Patterson GT, and Dettbarn WD. Changes in skeletal muscle properties following hindlimb suspension. Physiologist 28: S133-134, 1985.
552.Patterson-Buckendahl P, Globus RK, Bikle DD, Cann CE, and Morey-Holton E. Effects of simulated weightlessness on rat osteocalcin and bone calcium. Am J Physiol 257: R1103-1109, 1989.
553.Pattison A, Pattison T, and Schechter J. Pars distalis vasculature: Discovery Shuttle STS-29 rats compared to ground-based antiorthostatic rats. Anat Rec 231: 347-350, 1991.
554.Pecaut MJ, Simske SJ, and Fleshner M. Spaceflight induces changes in splenocyte subpopulations: effectiveness of ground-based models. Am J Physiol Regul Integr Comp Physiol 279: R2072-2078, 2000.
555.Pedrini-Mille A, Maynard JA, Durnova GN, Kaplansky AS, Pedrini VA, Chung CB, and Fedler-Troester J. Effects of microgravity on the composition