| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
INVITED REVIEW
Department of Physiological Science, University of California, Los Angeles, California
Currently, modern chronic diseases, including cardiovascular diseases, Type 2 diabetes, metabolic syndrome, and cancer, are the leading killers in Westernized society and are increasing rampantly in developing nations. In fact, obesity, diabetes, and hypertension are now even commonplace in children. Clearly, however, there is a solution to this epidemic of metabolic disease that is inundating today’s societies worldwide: exercise and diet. Overwhelming evidence from a variety of sources, including epidemiological, prospective cohort, and intervention studies, links most chronic diseases seen in the world today to physical inactivity and inappropriate diet consumption. The purpose of this review is to 1) discuss the effects of exercise and diet in the prevention of chronic disease, 2) highlight the effects of lifestyle modification for both mitigating disease progression and reversing existing disease, and 3) suggest potential mechanisms for beneficial effects.
cancer; diabetes; coronary artery disease; hypertension; metabolic syndrome
This article has been cited by other articles:
|
|
 |
|
  C. K. Roberts, R. J. Barnard, D. M. Croymans, A. Astrup, K. Moller, R. Krogh-Madsen, D. Ornish, G. M. Manzoni, G. Castelnuovo, E. Molinari, et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N. Engl. J. Med., November 13, 2008; 359(20): 2169 - 2170. [Full Text] [PDF]
|
|
|
|
 |
|
 P Borrione, M Rizzo, A Spaccamiglio, R A Salvo, A Dovio, A Termine, A Parisi, F Fagnani, A Angeli, and F Pigozzi Sport-related hyperhomocysteinaemia: a putative marker of muscular demand to be noted for cardiovascular risk Br. J. Sports Med., November 1, 2008; 42(11): 594 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M Merrill, S. G Aldana, R. L Greenlaw, A. Salberg, and H. Englert Chronic disease risk reduction with a community-based lifestyle change programme Health Education Journal, September 1, 2008; 67(3): 219 - 230. [Abstract] [PDF]
|
|
|
|
 |
|
 R. M. Steele, S. Brage, K. Corder, N. J. Wareham, and U. Ekelund Physical activity, cardiorespiratory fitness, and the metabolic syndrome in youth J Appl Physiol, July 1, 2008; 105(1): 342 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Lightfoot, M. J. Turner, D. Pomp, S. R. Kleeberger, and L. J. Leamy Quantitative trait loci for physical activity traits in mice Physiol Genomics, February 19, 2008; 32(3): 401 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Rooks, S. Gautam, M. Romeling, M. L. Cross, D. Stratigakis, B. Evans, D. L. Goldenberg, M. D. Iversen, and J. N. Katz Group Exercise, Education, and Combination Self-management in Women With Fibromyalgia: A Randomized Trial Arch Intern Med, November 12, 2007; 167(20): 2192 - 2200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Hunnell, N. J. Rockcastle, K. N. McCormick, L. K. Sinko, E. L. Sullivan, and J. L. Cameron Physical activity of adult female rhesus monkeys (Macaca mulatta) across the menstrual cycle Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1520 - E1525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Geiger, C. Hancock, D. C. Wright, D.-H. Han, and J. O. Holloszy IL-6 increases muscle insulin sensitivity only at superphysiological levels Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1842 - E1846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Buttner, S. Mosig, A. Lechtermann, H. Funke, and F. C. Mooren Exercise affects the gene expression profiles of human white blood cells J Appl Physiol, January 1, 2007; 102(1): 26 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Frisbee, J. B. Samora, J. Peterson, and R. Bryner Exercise training blunts microvascular rarefaction in the metabolic syndrome Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2483 - H2492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. H. Mortensen, L. Frandsen, P. Schjerling, E. Nishimura, and N. Grunnet PGC-1{alpha} and PGC-1beta have both similar and distinct effects on myofiber switching toward an oxidative phenotype Am J Physiol Endocrinol Metab, October 1, 2006; 291(4): E807 - E816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Parsons, H. B. Carter, A. W. Partin, B. G. Windham, E. J. Metter, L. Ferrucci, P. Landis, and E. A. Platz Metabolic Factors Associated with Benign Prostatic Hyperplasia J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2562 - 2568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Roberts, D. Won, S. Pruthi, S. Kurtovic, R. K. Sindhu, N. D. Vaziri, and R. J. Barnard Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors J Appl Physiol, May 1, 2006; 100(5): 1657 - 1665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kalani, S. Judge, C. Carter, M. Pahor, and C. Leeuwenburgh Effects of Caloric Restriction and Exercise on Age-Related, Chronic Inflammation Assessed by C-Reactive Protein and Interleukin-6. J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2006; 61(3): 211 - 217. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
