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Cover: Trichrome stain of rat lungs showing effects of hypoxia and atrial (ANP) and brain natriuretic peptide (BNP) on muscularization of peripheral pulmonary vessels. Rats were given continuous infusion of saline, ANP, and BNP during 3 wk of normoxia or hypoxia. Top left: saline/normoxia; top right: saline/hypoxia; bottom left: ANP/hypoxia; bottom right: BNP/hypoxia. Arrows indicate proliferation of smooth muscle (dark areas). Magnification ×600. (From Klinger et al. J. Appl. Physiol. 84: 1646-1652, 1998.)
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