ESSAYS ON APS CLASSIC PAPERS

Hershel Raff, Dale Benos, and Margaret Reich

Editorial  Introduction to the classic papers commemorating the APS Legacy Project
J Appl Physiol 97: 1589-1590, 2004; doi:10.1152/classicessays.00001.2004 [Full Text] [PDF]  

Christopher P. Ingalls

Editorial Focus  Nature vs. nurture: can exercise really alter fiber type composition in human skeletal muscle?
J Appl Physiol 97: 1591-1592, 2004; doi:10.1152/classicessays.00010.2004 [Abstract] [Full Text] [PDF]  

Gary W. Mack

Editorial Focus  Hypothalamic control of body temperature: insights from the past
J Appl Physiol 97: 1593-1594, 2004; doi:10.1152/classicessays.00011.2004 [Abstract] [Full Text] [PDF]  

Judith A. Neubauer

Editorial Focus  Comroe's study of aortic chemoreceptors: a path well chosen
J Appl Physiol 97: 1595-1596, 2004; doi:10.1152/classicessays.00015.2004 [Abstract] [Full Text] [PDF]  

Hershel Raff

Editorial Focus  The significance of the blood gas analyzer
J Appl Physiol 97: 1597-1598, 2004; doi:10.1152/classicessays.00016.2004 [Abstract] [Full Text] [PDF]  

John W. Severinghaus

Editorial Focus  First electrodes for blood PO₂ and PCO₂ determination
J Appl Physiol 97: 1599-1600, 2004; doi:10.1152/classicessays.00021.2004 [Abstract] [Full Text] [PDF]  

Richard J. Traystman

Editorial Focus  The paper that completely altered our thinking about cerebral blood flow measurement
J Appl Physiol 97: 1601-1602, 2004; doi:10.1152/classicessays.00023.2004 [Abstract] [Full Text] [PDF]  

John B. West

Editorial Focus  Understanding pulmonary gas exchange: ventilation-perfusion relationships
J Appl Physiol 97: 1603-1604, 2004; doi:10.1152/classicessays.00024.2004 [Abstract] [Full Text] [PDF]  

INVITED EDITORIAL

Donald R. McCrimmon and George F. Alheid

Capra, eupnea, dyspnea, apnea: respiratory rhythms and the pre-Bötzinger complex in the goat
J Appl Physiol 97: 1618-1619, 2004; doi:10.1152/japplphysiol.00627.2004 [Full Text] [PDF]  

INVITED REVIEW

Marco Mura, Claudia C. dos Santos, Duncan Stewart, and Mingyao Liu

Vascular endothelial growth factor and related molecules in acute lung injury
J Appl Physiol 97: 1605-1617, 2004; doi:10.1152/japplphysiol.00202.2004 [Abstract] [Full Text] [PDF]  

REPORT

Bryan C. Rourke, Anqi Qin, Fadia Haddad, Kenneth M. Baldwin, and Vincent J. Caiozzo

Cloning and sequencing of myosin heavy chain isoform cDNAs in golden-mantled ground squirrels: effects of hibernation on mRNA expression
J Appl Physiol 97: 1985-1991, 2004. First published August 6, 2004; doi:10.1152/japplphysiol.00695.2004 [Abstract] [Full Text] [PDF]  

TRANSLATIONAL PHYSIOLOGY

Nicola Laws and Andrew Hoey

Progression of kyphosis in mdx mice
J Appl Physiol 97: 1970-1977, 2004. First published July 2, 2004; doi:10.1152/japplphysiol.01357.2003 [Abstract] [Full Text] [PDF]  

William G. Schrage, John H. Eisenach, Frank A. Dinenno, Shelly K. Roberts, Christopher P. Johnson, Paola Sandroni, Philip A. Low, and Michael J. Joyner

Effects of midodrine on exercise-induced hypotension and blood pressure recovery in autonomic failure
J Appl Physiol 97: 1978-1984, 2004. First published July 23, 2004; doi:10.1152/japplphysiol.00547.2004 [Abstract] [Full Text] [PDF]  

ARTICLES

J. M. Wenninger, L. G. Pan, L. Klum, T. Leekley, J. Bastastic, M. R. Hodges, T. Feroah, S. Davis, and H. V. Forster

Small reduction of neurokinin-1 receptor-expressing neurons in the pre-Bötzinger complex area induces abnormal breathing periods in awake goats
J Appl Physiol 97: 1620-1628, 2004. First published July 9, 2004; doi:10.1152/japplphysiol.00952.2003 [Abstract] [Full Text] [PDF]  

J. M. Wenninger, L. G. Pan, L. Klum, T. Leekley, J. Bastastic, M. R. Hodges, T. R. Feroah, S. Davis, and H. V. Forster

Large lesions in the pre-Bötzinger complex area eliminate eupneic respiratory rhythm in awake goats
J Appl Physiol 97: 1629-1636, 2004. First published July 9, 2004; doi:10.1152/japplphysiol.00953.2003 [Abstract] [Full Text] [PDF]  

Paolo Palange, Gabriele Valli, Paolo Onorati, Rosa Antonucci, Patrizia Paoletti, Alessia Rosato, Felice Manfredi, and Pietro Serra

Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients
J Appl Physiol 97: 1637-1642, 2004. First published July 2, 2004; doi:10.1152/japplphysiol.01207.2003 [Abstract] [Full Text] [PDF]  

C. William Thorpe, Cheryl M. Salome, Norbert Berend, and Gregory G. King

Modeling airway resistance dynamics after tidal and deep inspirations
J Appl Physiol 97: 1643-1653, 2004. First published July 16, 2004; doi:10.1152/japplphysiol.01300.2003 [Abstract] [Full Text] [PDF]  

Robert J. Spina, Timothy E. Meyer, Linda R. Peterson, Dennis T. Villareal, Morton R. Rinder, and Ali A. Ehsani

Absence of left ventricular and arterial adaptations to exercise in octogenarians
J Appl Physiol 97: 1654-1659, 2004; doi:10.1152/japplphysiol.01303.2003 [Abstract] [Full Text] [PDF]  

S. Marlene Grenon, Shelley Hurwitz, Natalie Sheynberg, Xinshu Xiao, Brad Judson, Craig D. Ramsdell, Christine Kim, Richard J. Cohen, and Gordon H. Williams

Sleep restriction does not affect orthostatic tolerance in the simulated microgravity environment
J Appl Physiol 97: 1660-1666, 2004. First published July 2, 2004; doi:10.1152/japplphysiol.00328.2004 [Abstract] [Full Text] [PDF]  

Timothy E. Meyer, Mustafa Karamanoglu, Ali A. Ehsani, and Sándor J. Kovács

Left ventricular chamber stiffness at rest as a determinant of exercise capacity in heart failure subjects with decreased ejection fraction
J Appl Physiol 97: 1667-1672, 2004. First published June 18, 2004; doi:10.1152/japplphysiol.00078.2004 [Abstract] [Full Text] [PDF]  

Chris Morelli, M. Safwan Badr, and Jason H. Mateika

Ventilatory responses to carbon dioxide at low and high levels of oxygen are elevated after episodic hypoxia in men compared with women
J Appl Physiol 97: 1673-1680, 2004. First published July 23, 2004; doi:10.1152/japplphysiol.00541.2004 [Abstract] [Full Text] [PDF]  

Ken Tokizawa, Masaki Mizuno, Yoshio Nakamura, and Isao Muraoka

Passive triceps surae stretch inhibits vasoconstriction in the nonexercised limb during posthandgrip muscle ischemia
J Appl Physiol 97: 1681-1685, 2004. First published July 23, 2004; doi:10.1152/japplphysiol.00312.2004 [Abstract] [Full Text] [PDF]  

Jennifer Powers and Daniel Bernstein

The mouse as a model of cardiovascular adaptations to microgravity
J Appl Physiol 97: 1686-1692, 2004. First published July 16, 2004; doi:10.1152/japplphysiol.00925.2003 [Abstract] [Full Text] [PDF]  

C. J. de Ruiter, R. D. Kooistra, M. I. Paalman, and A. de Haan

Initial phase of maximal voluntary and electrically stimulated knee extension torque development at different knee angles
J Appl Physiol 97: 1693-1701, 2004. First published June 4, 2004; doi:10.1152/japplphysiol.00230.2004 [Abstract] [Full Text] [PDF]  

Carmel Schimmel, Susan L. Bernard, Joseph C. Anderson, Nayak L. Polissar, S. Lakshminarayan, and Michael P. Hlastala

Soluble gas exchange in the pulmonary airways of sheep
J Appl Physiol 97: 1702-1708, 2004. First published June 25, 2004; doi:10.1152/japplphysiol.01272.2003 [Abstract] [Full Text] [PDF]  

Jianhua Li, Michael D. Maile, Adam N. Sinoway, and Lawrence I. Sinoway

Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel
J Appl Physiol 97: 1709-1714, 2004. First published June 25, 2004; doi:10.1152/japplphysiol.00389.2004 [Abstract] [Full Text] [PDF]  

A. Jeroen Verheul, Carlos B. Mantilla, Wen-Zhi Zhan, Miguel Bernal, P. N. Richard Dekhuijzen, and Gary C. Sieck

Influence of corticosteroids on myonuclear domain size in the rat diaphragm muscle
J Appl Physiol 97: 1715-1722, 2004. First published July 2, 2004; doi:10.1152/japplphysiol.00625.2003 [Abstract] [Full Text] [PDF]  

Sandra K. Hunter, Ashley Critchlow, and Roger M. Enoka

Influence of aging on sex differences in muscle fatigability
J Appl Physiol 97: 1723-1732, 2004. First published June 18, 2004; doi:10.1152/japplphysiol.00460.2004 [Abstract] [Full Text] [PDF]  

Mads K. Dalsgaard, Stefanos Volianitis, Chie C. Yoshiga, Ellen A. Dawson, and Niels H. Secher

Cerebral metabolism during upper and lower body exercise
J Appl Physiol 97: 1733-1739, 2004. First published June 18, 2004; doi:10.1152/japplphysiol.00450.2004 [Abstract] [Full Text] [PDF]  

William J. Durham, Yi-Ping Li, Eric Gerken, Mehran Farid, Sandrine Arbogast, Robert R. Wolfe, and Michael B. Reid

Fatiguing exercise reduces DNA binding activity of NF-B in skeletal muscle nuclei
J Appl Physiol 97: 1740-1745, 2004. First published June 18, 2004; doi:10.1152/japplphysiol.00088.2004 [Abstract] [Full Text] [PDF]  

Guo-Qing Zhu, Lie Gao, Kuashik P. Patel, Irving H. Zucker, and Wei Wang

ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure
J Appl Physiol 97: 1746-1754, 2004; doi:10.1152/japplphysiol.00573.2004 [Abstract] [Full Text] [PDF]  

Holger Schulz, Anne Schulz, Gunter Eder, and Joachim Heyder

Labeled carbon dioxide (C¹⁸O₂): an indicator gas for phase II in expirograms
J Appl Physiol 97: 1755-1762, 2004. First published June 11, 2004; doi:10.1152/japplphysiol.01360.2003 [Abstract] [Full Text] [PDF]  

Natalie C. Taylor, Aihua Li, Adam Green, Hannah C. Kinney, and Eugene E. Nattie

Chronic fluoxetine microdialysis into the medullary raphe nuclei of the rat, but not systemic administration, increases the ventilatory response to CO₂
J Appl Physiol 97: 1763-1773, 2004. First published July 23, 2004; doi:10.1152/japplphysiol.00496.2004 [Abstract] [Full Text] [PDF]  

Mitsuaki Sakai, Yukio Sato, Shoko Sato, Satoshi Ihara, Masataka Onizuka, Yuzuru Sakakibara, and Hideto Takahashi

Effect of relocating to areas of reduced atmospheric particulate matter levels on the human circulating leukocyte count
J Appl Physiol 97: 1774-1780, 2004. First published July 2, 2004; doi:10.1152/japplphysiol.00024.2004 [Abstract] [Full Text] [PDF]  

Sandrine Golay, Christian Haeberli, Anne Delachaux, Lucas Liaudet, Paul Kucera, Bernard Waeber, and François Feihl

Local heating of human skin causes hyperemia without mediation by muscarinic cholinergic receptors or prostanoids
J Appl Physiol 97: 1781-1786, 2004. First published July 9, 2004; doi:10.1152/japplphysiol.00814.2003 [Abstract] [Full Text] [PDF]  

Lee Friedman, Abby Haines, Ken Klann, Laura Gallaugher, Lawrence Salibra, Fang Han, and Kingman P. Strohl

Ventilatory behavior during sleep among A/J and C57BL/6J mouse strains
J Appl Physiol 97: 1787-1795, 2004; doi:10.1152/japplphysiol.01394.2003 [Abstract] [Full Text] [PDF]  

M. Mourtzakis, J. González-Alonso, T. E. Graham, and B. Saltin

Hemodynamics and O₂ uptake during maximal knee extensor exercise in untrained and trained human quadriceps muscle: effects of hyperoxia
J Appl Physiol 97: 1796-1802, 2004. First published June 18, 2004; doi:10.1152/japplphysiol.00169.2004 [Abstract] [Full Text] [PDF]  

Tina J. Patel, Ronnie Das, Jan Fridén, Gordon J. Lutz, and Richard L. Lieber

Sarcomere strain and heterogeneity correlate with injury to frog skeletal muscle fiber bundles
J Appl Physiol 97: 1803-1813, 2004. First published June 18, 2004; doi:10.1152/japplphysiol.00505.2003 [Abstract] [Full Text] [PDF]  

Louis G. Chicoine, Edith Tzeng, Rebekah Bryan, Steven Saenz, Michael L. Paffett, Joelle Jones, C. Richard Lyons, Thomas C. Resta, Leif D. Nelin, and Benjimen R. Walker

Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats
J Appl Physiol 97: 1814-1822, 2004. First published July 16, 2004; doi:10.1152/japplphysiol.00193.2004 [Abstract] [Full Text] [PDF]  

Todd W. Mitchell, Nigel Turner, A. J. Hulbert, Paul L. Else, John A. Hawley, Jong Sam Lee, Clinton R. Bruce, and Stephen J. Blanksby

Exercise alters the profile of phospholipid molecular species in rat skeletal muscle
J Appl Physiol 97: 1823-1829, 2004. First published June 18, 2004; doi:10.1152/japplphysiol.00344.2004 [Abstract] [Full Text] [PDF]  

D. N. Baldwin, B. Suki, J. J. Pillow, H. L. Roiha, S. Minocchieri, and U. Frey

Effect of sighs on breathing memory and dynamics in healthy infants
J Appl Physiol 97: 1830-1839, 2004. First published June 18, 2004; doi:10.1152/japplphysiol.00298.2004 [Abstract] [Full Text] [PDF]  

Khaled F. Mansour, James A. Rowley, and M. Safwan Badr

Noninvasive determination of upper airway resistance and flow limitation
J Appl Physiol 97: 1840-1848, 2004. First published May 28, 2004; doi:10.1152/japplphysiol.01319.2003 [Abstract] [Full Text] [PDF]  

David A. Kaminsky, Charles G. Irvin, Lennart Lundblad, Henrique T. Moriya, Sherburn Lang, Jennifer Allen, Tracey Viola, Mary Lynn, and Jason H. T. Bates

Oscillation mechanics of the human lung periphery in asthma
J Appl Physiol 97: 1849-1858, 2004. First published June 25, 2004; doi:10.1152/japplphysiol.00300.2004 [Abstract] [Full Text] [PDF]  

J. M. Welch, C. M. Weaver, and C. H. Turner

Adaptations to free-fall impact are different in the shafts and bone ends of rat forelimbs
J Appl Physiol 97: 1859-1865, 2004. First published July 16, 2004; doi:10.1152/japplphysiol.00438.2004 [Abstract] [Full Text] [PDF]  

Marco Guazzi, Giuseppe Reina, Gabriele Tumminello, and Maurizio D. Guazzi

Improvement of alveolar-capillary membrane diffusing capacity with exercise training in chronic heart failure
J Appl Physiol 97: 1866-1873, 2004. First published June 25, 2004; doi:10.1152/japplphysiol.00365.2004 [Abstract] [Full Text] [PDF]  

Christine Donzel-Raynaud, Christian Straus, Michela Bezzi, Stefania Redolfi, Mathieu Raux, Marc Zelter, Jean-Philippe Derenne, and Thomas Similowski

Upper airway afferents are sufficient to evoke the early components of respiratory-related cortical potentials in humans
J Appl Physiol 97: 1874-1879, 2004. First published June 25, 2004; doi:10.1152/japplphysiol.01381.2003 [Abstract] [Full Text] [PDF]  

Derek W. Brown, David Lee, Vazhkudai S. Kumaran, and Ting-Yim Lee

Age-dependent cerebral hemodynamic effects of indomethacin in the newborn piglet
J Appl Physiol 97: 1880-1887, 2004. First published July 9, 2004; doi:10.1152/japplphysiol.01396.2003 [Abstract] [Full Text] [PDF]  

Cristina Márcia Dias, Caroline P. Pássaro, Viviane Ramos Cagido, Marcelo Einicker-Lamas, Jennifer Lowe, Elnara M. Negri, Vera L. Capelozzi, Walter A. Zin, and Patricia R. M. Rocco

Effects of undernutrition on respiratory mechanics and lung parenchyma remodeling
J Appl Physiol 97: 1888-1896, 2004. First published June 11, 2004; doi:10.1152/japplphysiol.00091.2004 [Abstract] [Full Text] [PDF]  

K. E. Macey, P. M. Macey, M. A. Woo, R. K. Harper, J. R. Alger, T. G. Keens, and R. M. Harper

fMRI signal changes in response to forced expiratory loading in congenital central hypoventilation syndrome
J Appl Physiol 97: 1897-1907, 2004. First published July 16, 2004; doi:10.1152/japplphysiol.00359.2004 [Abstract] [Full Text] [PDF]  

Jens Bojsen-Møller, Philip Hansen, Per Aagaard, Ulla Svantesson, Michael Kjaer, and S. Peter Magnusson

Differential displacement of the human soleus and medial gastrocnemius aponeuroses during isometric plantar flexor contractions in vivo
J Appl Physiol 97: 1908-1914, 2004. First published June 25, 2004; doi:10.1152/japplphysiol.00084.2004 [Abstract] [Full Text] [PDF]  

Wayne A. Van Voorhies, Aziz A. Khazaeli, and James W. Curtsinger

Testing the "rate of living" model: further evidence that longevity and metabolic rate are not inversely correlated in Drosophila melanogaster
J Appl Physiol 97: 1915-1922, 2004. First published July 2, 2004; doi:10.1152/japplphysiol.00505.2004 [Abstract] [Full Text] [PDF]  

V. Martin, G. Y. Millet, A. Martin, G. Deley, and G. Lattier

Assessment of low-frequency fatigue with two methods of electrical stimulation
J Appl Physiol 97: 1923-1929, 2004. First published July 16, 2004; doi:10.1152/japplphysiol.00376.2004 [Abstract] [Full Text] [PDF]  

Randal O. Dull, Bracken J. DeWitt, Ramani Dinavahi, Larry Schwartz, Christopher Hubert, Nathan Pace, and Clara Fronticelli

Quantitative assessment of hemoglobin-induced endothelial barrier dysfunction
J Appl Physiol 97: 1930-1937, 2004. First published July 23, 2004; doi:10.1152/japplphysiol.00102.2004 [Abstract] [Full Text] [PDF]  

Marcus O'Neill, Matthew J. Watt, George J. F. Heigenhauser, and Lawrence L. Spriet

Effects of reduced free fatty acid availability on hormone-sensitive lipase activity in human skeletal muscle during aerobic exercise
J Appl Physiol 97: 1938-1945, 2004. First published June 18, 2004; doi:10.1152/japplphysiol.01135.2003 [Abstract] [Full Text] [PDF]  

Christopher J. Danek, Charles M. Lombard, Donald L. Dungworth, P. Gerard Cox, John D. Miller, Michael J. Biggs, Thomas M. Keast, Bryan E. Loomas, William J. Wizeman, James C. Hogg, and Alan R. Leff

Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs
J Appl Physiol 97: 1946-1953, 2004. First published July 16, 2004; doi:10.1152/japplphysiol.01282.2003 [Abstract] [Full Text] [PDF]  

Charlotte Suetta, Per Aagaard, Anna Rosted, Ane K. Jakobsen, Benn Duus, Michael Kjaer, and S. Peter Magnusson

Training-induced changes in muscle CSA, muscle strength, EMG, and rate of force development in elderly subjects after long-term unilateral disuse
J Appl Physiol 97: 1954-1961, 2004. First published July 9, 2004; doi:10.1152/japplphysiol.01307.2003 [Abstract] [Full Text] [PDF]  

INNOVATIVE METHODOLOGY

Egbert G. Mik, Ton G. van Leeuwen, Nicolaas J. Raat, and Can Ince

Quantitative determination of localized tissue oxygen concentration in vivo by two-photon excitation phosphorescence lifetime measurements
J Appl Physiol 97: 1962-1969, 2004. First published July 9, 2004; doi:10.1152/japplphysiol.01399.2003 [Abstract] [Full Text] [PDF]  

HIGHLIGHTED TOPICS

Connie C. W. Hsia

Invited Review  Signals and mechanisms of compensatory lung growth
J Appl Physiol 97: 1992-1998, 2004; doi:10.1152/japplphysiol.00530.2004 [Abstract] [Full Text] [PDF]  

Wayne Mitzner and Elizabeth M. Wagner

Invited Review  Vascular remodeling in the circulations of the lung
J Appl Physiol 97: 1999-2004, 2004; doi:10.1152/japplphysiol.00473.2004 [Abstract] [Full Text] [PDF]  

Gary C. Sieck

Commentary 
J Appl Physiol 97: 2005-2005, 2004; doi:10.1152/japplphysiol.00920.2004 [Full Text] [PDF]  

Roderick J. Tan, Cheryl L. Fattman, Simon C. Watkins, and Tim D. Oury

Redistribution of pulmonary EC-SOD after exposure to asbestos
J Appl Physiol 97: 2006-2013, 2004. First published August 6, 2004; doi:10.1152/japplphysiol.00480.2004 [Abstract] [Full Text] [PDF]  

Simone A. J. ter Horst, Gerry T. M. Wagenaar, Eveline de Boer, Margôt A. van Gastelen, Joost C. M. Meijers, Bart J. Biemond, Ben J. H. M. Poorthuis, and Frans J. Walther

Pentoxifylline reduces fibrin deposition and prolongs survival in neonatal hyperoxic lung injury
J Appl Physiol 97: 2014-2019, 2004. First published June 18, 2004; doi:10.1152/japplphysiol.00452.2004 [Abstract] [Full Text] [PDF]  

Ying-Jie Peng, Julie Rennison, and Nanduri R. Prabhakar

Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups
J Appl Physiol 97: 2020-2025, 2004. First published July 16, 2004; doi:10.1152/japplphysiol.00876.2003 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR

Oleg Verbitsky

What mechanism is responsible for the decreased BE/[La] ratio in exercise-induced metabolic acidosis?
J Appl Physiol 97: 2026-2027, 2004; doi:10.1152/japplphysiol.00731.2004 [Full Text] [PDF]  

CORRIGENDA

CORRIGENDUM
J Appl Physiol 97: 2028-2028, 2004; doi:10.1152/japplphysiol.00918.2004 [Full Text] [PDF]  

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