INVITED EDITORIALS

Joris R. Delanghe and Michael J. Joyner

Testing for recombinant human erythropoietin
J Appl Physiol 105: 395-396, 2008. First published June 26, 2008; doi:10.1152/japplphysiol.90746.2008 [Full Text] [PDF]  

Michael Rennie

Mysterious properties of tendon metabolism
J Appl Physiol 105: 397-397, 2008. First published May 15, 2008; doi:10.1152/japplphysiol.90638.2008 [Full Text] [PDF]  

Christopher T. Minson and Daniel J. Green

Measures of vascular reactivity: prognostic crystal ball or Pandora's box?
J Appl Physiol 105: 398-399, 2008. First published June 12, 2008; doi:10.1152/japplphysiol.90741.2008 [Full Text] [PDF]  

Frank Christian Pott

Hot topic—cerebral hemodynamics in the heat
J Appl Physiol 105: 400-401, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.90711.2008 [Full Text] [PDF]  

Wayne Mitzner

Why can't mice just learn to pant?
J Appl Physiol 105: 402-402, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.90713.2008 [Full Text] [PDF]  

T. G. Lohman

Six-year longitudinal analysis shows physical activity impacts on lean mass development in adolescence
J Appl Physiol 105: 403-403, 2008. First published June 12, 2008; doi:10.1152/japplphysiol.90725.2008 [Full Text] [PDF]  

INVITED REVIEW

Patrice G. Guyenet

The 2008 Carl Ludwig Lecture: retrotrapezoid nucleus, CO₂ homeostasis, and breathing automaticity
J Appl Physiol 105: 404-416, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.90452.2008 [Abstract] [Full Text] [PDF]  

ARTICLES

Carsten Lundby, Niels J. Achman-Andersen, Jonas J. Thomsen, Anne M. Norgaard, and Paul Robach

Testing for recombinant human erythropoietin in urine: problems associated with current anti-doping testing
J Appl Physiol 105: 417-419, 2008. First published June 26, 2008; doi:10.1152/japplphysiol.90529.2008 [Abstract] [Full Text] [PDF]  

Britt Christensen, Eva Dyrberg, Per Aagaard, Susanne Enehjelm, Michael Krogsgaard, Michael Kjær, and Henning Langberg

Effects of long-term immobilization and recovery on human triceps surae and collagen turnover in the Achilles tendon in patients with healing ankle fracture
J Appl Physiol 105: 420-426, 2008. First published April 10, 2008; doi:10.1152/japplphysiol.00201.2008 [Abstract] [Full Text] [PDF]  

Mandeep Dhindsa, Shawn M. Sommerlad, Allison E. DeVan, Jill N. Barnes, Jun Sugawara, Obdulia Ley, and Hirofumi Tanaka

Interrelationships among noninvasive measures of postischemic macro- and microvascular reactivity
J Appl Physiol 105: 427-432, 2008. First published May 15, 2008; doi:10.1152/japplphysiol.90431.2008 [Abstract] [Full Text] [PDF]  

Jui-Lin Fan, James D. Cotter, Rebekah A. I. Lucas, Kate Thomas, Luke Wilson, and Philip N. Ainslie

Human cardiorespiratory and cerebrovascular function during severe passive hyperthermia: effects of mild hypohydration
J Appl Physiol 105: 433-445, 2008. First published May 15, 2008; doi:10.1152/japplphysiol.00010.2008 [Abstract] [Full Text] [PDF]  

Alan R. Barker, Joanne R. Welsman, Jonathan Fulford, Deborah Welford, and Neil Armstrong

Muscle phosphocreatine kinetics in children and adults at the onset and offset of moderate-intensity exercise
J Appl Physiol 105: 446-456, 2008. First published May 22, 2008; doi:10.1152/japplphysiol.00819.2007 [Abstract] [Full Text] [PDF]  

Eun-Jeong Lee and Walter Herzog

Residual force enhancement exceeds the isometric force at optimal sarcomere length for optimized stretch conditions
J Appl Physiol 105: 457-462, 2008. First published May 22, 2008; doi:10.1152/japplphysiol.01109.2006 [Abstract] [Full Text] [PDF]  

Sandra K. Hunter, Tejin Yoon, Joseph Farinella, Erin E. Griffith, and Alexander V. Ng

Time to task failure and muscle activation vary with load type for a submaximal fatiguing contraction with the lower leg
J Appl Physiol 105: 463-472, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.90398.2008 [Abstract] [Full Text] [PDF]  

Charles P. Lambert, Nicole R. Wright, Brian N. Finck, and Dennis T. Villareal

Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons
J Appl Physiol 105: 473-478, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.00006.2008 [Abstract] [Full Text] [PDF]  

Adam S. LaPrad, Adrian R. West, Peter B. Noble, Kenneth R. Lutchen, and Howard W. Mitchell

Maintenance of airway caliber in isolated airways by deep inspiration and tidal strains
J Appl Physiol 105: 479-485, 2008. First published June 12, 2008; doi:10.1152/japplphysiol.01220.2007 [Abstract] [Full Text] [PDF]  

C. P. McGowan, R. R. Neptune, and R. Kram

Independent effects of weight and mass on plantar flexor activity during walking: implications for their contributions to body support and forward propulsion
J Appl Physiol 105: 486-494, 2008. First published June 12, 2008; doi:10.1152/japplphysiol.90448.2008 [Abstract] [Full Text] [PDF]  

Darcy L. Johannsen, James P. DeLany, Madlyn I. Frisard, Michael A. Welsch, Christina K. Rowley, Xiaobing Fang, S. Michal Jazwinski, Eric Ravussin The Louisiana Healthy Aging Study

Physical activity in aging: Comparison among young, aged, and nonagenarian individuals
J Appl Physiol 105: 495-501, 2008. First published June 12, 2008; doi:10.1152/japplphysiol.90450.2008 [Abstract] [Full Text] [PDF]  

Tanya S. Turner, Kylie J. Tucker, Nigel C. Rogasch, and John G. Semmler

Impaired neuromuscular function during isometric, shortening, and lengthening contractions after exercise-induced damage to elbow flexor muscles
J Appl Physiol 105: 502-509, 2008. First published June 12, 2008; doi:10.1152/japplphysiol.90421.2008 [Abstract] [Full Text] [PDF]  

Marianna E. Jung, James W. Simpkins, Andrew M. Wilson, H. Fred Downey, and Robert T. Mallet

Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn rats
J Appl Physiol 105: 510-517, 2008. First published May 22, 2008; doi:10.1152/japplphysiol.90317.2008 [Abstract] [Full Text] [PDF]  

Motoo Yamauchi, Jesse Dostal, Hiroshi Kimura, and Kingman P. Strohl

Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains
J Appl Physiol 105: 518-526, 2008. First published May 29, 2008; doi:10.1152/japplphysiol.00069.2008 [Abstract] [Full Text] [PDF]  

Benjamin T. Corona, Clement Rouviere, Susan L. Hamilton, and Christopher P. Ingalls

FKBP12 deficiency reduces strength deficits after eccentric contraction-induced muscle injury
J Appl Physiol 105: 527-537, 2008. First published May 29, 2008; doi:10.1152/japplphysiol.01145.2007 [Abstract] [Full Text] [PDF]  

Fred J. DiMenna, Daryl P. Wilkerson, Mark Burnley, and Andrew M. Jones

Influence of priming exercise on pulmonary O₂ uptake kinetics during transitions to high-intensity exercise from an elevated baseline
J Appl Physiol 105: 538-546, 2008. First published May 29, 2008; doi:10.1152/japplphysiol.90357.2008 [Abstract] [Full Text] [PDF]  

M. Mourtzakis, T. E. Graham, J. González-Alonso, and B. Saltin

Glutamate availability is important in intramuscular amino acid metabolism and TCA cycle intermediates but does not affect peak oxidative metabolism
J Appl Physiol 105: 547-554, 2008. First published May 29, 2008; doi:10.1152/japplphysiol.90394.2008 [Abstract] [Full Text] [PDF]  

Richard J. Barker and Matthew R. Schofield

Classifying individuals as physiological responders using hierarchical modeling
J Appl Physiol 105: 555-560, 2008. First published May 29, 2008; doi:10.1152/japplphysiol.01317.2007 [Abstract] [Full Text] [PDF]  

Marcel den Hoed, Matthijs K. C. Hesselink, Gerrit P. J. van Kranenburg, and Klaas R. Westerterp

Habitual physical activity in daily life correlates positively with markers for mitochondrial capacity
J Appl Physiol 105: 561-568, 2008. First published May 29, 2008; doi:10.1152/japplphysiol.00091.2008 [Abstract] [Full Text] [PDF]  

Wen Yin, Jin-Cheng Liu, Rong Fan, Xi-Qing Sun, Jin Ma, Na Feng, Quan Yu Zhang, Zhao Yin, Shu-Miao Zhang, Hai-Tao Guo, Hui Bi, Yue-Min Wang, Xin Sun, Liang Cheng, Qin Cui, Shi-Qiang Yu, Ding-Hua Yi, and Jian-Ming Pei

Modulation of β-adrenoceptor signaling in the hearts of 4-wk simulated weightlessness rats
J Appl Physiol 105: 569-574, 2008. First published May 29, 2008; doi:10.1152/japplphysiol.01381.2007 [Abstract] [Full Text] [PDF]  

Jerzy A. Zoladz, L. Bruce Gladden, Michael C. Hogan, Zenon Nieckarz, and Bruno Grassi

Progressive recruitment of muscle fibers is not necessary for the slow component of O₂ kinetics
J Appl Physiol 105: 575-580, 2008. First published May 15, 2008; doi:10.1152/japplphysiol.01129.2007 [Abstract] [Full Text] [PDF]  

C. Lundby, P. Robach, R. Boushel, J. J. Thomsen, P. Rasmussen, M. Koskolou, and J. A. L. Calbet

Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport?
J Appl Physiol 105: 581-587, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.90484.2008 [Abstract] [Full Text] [PDF]  

Tatiana Gardeazábal, Mariana Cabrera, Pedro Cabrales, Marcos Intaglietta, and Juan Carlos Briceño

Oxygen transport during hemodilution with a perfluorocarbon-based oxygen carrier: effect of altitude and hyperoxia
J Appl Physiol 105: 588-594, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.00152.2008 [Abstract] [Full Text] [PDF]  

Wen-Hong Kan, Chi-Hsun Hsieh, Martin G. Schwacha, Mashkoor A. Choudhry, Raghavan Raju, Kirby I. Bland, and Irshad H. Chaudry

Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis
J Appl Physiol 105: 595-602, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.00012.2008 [Abstract] [Full Text] [PDF]  

Graeme R. Polglase, Timothy J. M. Moss, Ilias Nitsos, Beth J. Allison, J. Jane Pillow, and Stuart B. Hooper

Differential effect of recruitment maneuvres on pulmonary blood flow and oxygenation during HFOV in preterm lambs
J Appl Physiol 105: 603-610, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.00041.2008 [Abstract] [Full Text] [PDF]  

Y. L. Kuo and C. J. Lai

Ovalbumin sensitizes vagal pulmonary C-fiber afferents in Brown Norway rats
J Appl Physiol 105: 611-620, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.01099.2007 [Abstract] [Full Text] [PDF]  

William J. McCarty, Melissa F. Chimento, Christine A. Curcio, and Mark Johnson

Effects of particulates and lipids on the hydraulic conductivity of Matrigel
J Appl Physiol 105: 621-628, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.01245.2007 [Abstract] [Full Text] [PDF]  

Matthew Harber and Scott Trappe

Single muscle fiber contractile properties of young competitive distance runners
J Appl Physiol 105: 629-636, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.00995.2007 [Abstract] [Full Text] [PDF]  

Walter R. Frontera, Kieran F. Reid, Edward M. Phillips, Lisa S. Krivickas, Virginia A. Hughes, Ronenn Roubenoff, and Roger A. Fielding

Muscle fiber size and function in elderly humans: a longitudinal study
J Appl Physiol 105: 637-642, 2008. First published June 12, 2008; doi:10.1152/japplphysiol.90332.2008 [Abstract] [Full Text] [PDF]  

Stuart D. R. Galloway, Jason L. Talanian, Anna K. Shoveller, George J. F. Heigenhauser, and Lawrence L. Spriet

Seven days of oral taurine supplementation does not increase muscle taurine content or alter substrate metabolism during prolonged exercise in humans
J Appl Physiol 105: 643-651, 2008. First published June 26, 2008; doi:10.1152/japplphysiol.90525.2008 [Abstract] [Full Text] [PDF]  

Evren U. Azeloglu, Jahar Bhattacharya, and Kevin D. Costa

Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffness
J Appl Physiol 105: 652-661, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.00958.2007 [Abstract] [Full Text] [PDF]  

Nicola Laws, Renée A. Cornford-Nairn, Nicole Irwin, Russell Johnsen, Susan Fletcher, Stephen D. Wilton, and Andrew J. Hoey

Long-term administration of antisense oligonucleotides into the paraspinal muscles of mdx mice reduces kyphosis
J Appl Physiol 105: 662-668, 2008. First published May 22, 2008; doi:10.1152/japplphysiol.00068.2008 [Abstract] [Full Text] [PDF]  

Scott Shofer, Cristian Badea, Yi Qi, Erin Potts, W. Michael Foster, and G. Allan Johnson

A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury
J Appl Physiol 105: 669-677, 2008. First published June 19, 2008; doi:10.1152/japplphysiol.00980.2007 [Abstract] [Full Text] [PDF]  

Akio Mizutani, Perenlei Enkhbaatar, Aimalohi Esechie, Lillian D. Traber, Robert A. Cox, Hal K. Hawkins, Donald J. Deyo, Kazunori Murakami, Takayuki Noguchi, and Daniel L. Traber

Pulmonary changes in a mouse model of combined burn and smoke inhalation-induced injury
J Appl Physiol 105: 678-684, 2008. First published April 24, 2008; doi:10.1152/japplphysiol.00232.2007 [Abstract] [Full Text] [PDF]  

Graeme R. Zosky, Tibor Z. Janosi, Ágnes Adamicza, Elizabeth M. Bozanich, Vincenzo Cannizzaro, Alexander N. Larcombe, Debra J. Turner, Peter D. Sly, and Zoltán Hantos

The bimodal quasi-static and dynamic elastance of the murine lung
J Appl Physiol 105: 685-692, 2008. First published June 12, 2008; doi:10.1152/japplphysiol.90328.2008 [Abstract] [Full Text] [PDF]  

INNOVATIVE METHODOLOGY

Andrea Evans, David G. McCormack, Giles Santyr, and Grace Parraga

Mapping and quantifying hyperpolarized ³He magnetic resonance imaging apparent diffusion coefficient gradients
J Appl Physiol 105: 693-699, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.00178.2008 [Abstract] [Full Text] [PDF]  

S. Hamid Nawab, Robert P. Wotiz, and Carlo J. De Luca

Decomposition of indwelling EMG signals
J Appl Physiol 105: 700-710, 2008. First published May 15, 2008; doi:10.1152/japplphysiol.00170.2007 [Abstract] [Full Text] [PDF]  

Jeffrey S. Reynolds, Victor J. Johnson, and David G. Frazer

Unrestrained acoustic plethysmograph for measuring specific airway resistance in mice
J Appl Physiol 105: 711-717, 2008. First published May 1, 2008; doi:10.1152/japplphysiol.00949.2007 [Abstract] [Full Text] [PDF]  

HIGHLIGHTED TOPICS

Thomas Rowland

Thermoregulation during exercise in the heat in children: old concepts revisited
J Appl Physiol 105: 718-724, 2008. First published December 13, 2007; doi:10.1152/japplphysiol.01196.2007 [Abstract] [Full Text] [PDF]  

Michael C. Riddell

The endocrine response and substrate utilization during exercise in children and adolescents
J Appl Physiol 105: 725-733, 2008. First published April 17, 2008; doi:10.1152/japplphysiol.00031.2008 [Abstract] [Full Text] [PDF]  

Adam D. G. Baxter-Jones, Joey C. Eisenmann, Robert L. Mirwald, Robert A. Faulkner, and Donald A. Bailey

The influence of physical activity on lean mass accrual during adolescence: a longitudinal analysis
J Appl Physiol 105: 734-741, 2008. First published May 8, 2008; doi:10.1152/japplphysiol.00869.2007 [Abstract] [Full Text] [PDF]  

M. C. Riddell, V. K. Jamnik, K. E. Iscoe, Brian W. Timmons, and N. Gledhill

Fat oxidation rate and the exercise intensity that elicits maximal fat oxidation decreases with pubertal status in young male subjects
J Appl Physiol 105: 742-748, 2008. First published June 5, 2008; doi:10.1152/japplphysiol.01256.2007 [Abstract] [Full Text] [PDF]  

POINT-COUNTERPOINT

Andrea Aliverti and Peter T. Macklem

The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles
J Appl Physiol 105: 749-751, 2008. First published March 20, 2008; doi:10.1152/japplphysiol.90336.2008 [Full Text] [PDF]  

Richard Debigaré and François Maltais

The major limitation to exercise performance in COPD is lower limb muscle dysfunction
J Appl Physiol 105: 751-753, 2008; doi:10.1152/japplphysiol.90336.2008a [Full Text] [PDF]  

Denis E. O'Donnell and Katherine A. Webb

The major limitation to exercise performance in COPD is dynamic hyperinflation
J Appl Physiol 105: 753-755, 2008; doi:10.1152/japplphysiol.90336.2008b [Full Text] [PDF]  

Rebuttal from Drs. Aliverti and Macklem
J Appl Physiol 105: 755-756, 2008; doi:10.1152/japplphysiol.90336.2008c [Full Text] [PDF]  

Rebuttal from Drs. Debigaré and Maltais
J Appl Physiol 105: 756-756, 2008; doi:10.1152/japplphysiol.90336.2008d [Full Text] [PDF]  

Rebuttal from Drs. O'Donnell and Webb
J Appl Physiol 105: 756-757, 2008; doi:10.1152/japplphysiol.90336.2008e [Full Text] [PDF]  

Andrea Aliverti and Peter T. Macklem

Last Word on Point:Counterpoint: The major limitation to exercise performance in COPD is 1) inadequate energy supply to the respiratory and locomotor muscles, 2) lower limb muscle dysfunction, 3) dynamic hyperinflation
J Appl Physiol 105: 763-763, 2008; doi:10.1152/japplphysiol.90745.2008 [Full Text] [PDF]  

Richard Debigaré and François Maltais

Last Word on Point:Counterpoint: The major limitation to exercise performance in COPD is 1) inadequate energy supply to the respiratory and locomotor muscles, 2) lower limb muscle dysfunction, 3) dynamic hyperinflation
J Appl Physiol 105: 764-764, 2008; doi:10.1152/japplphysiol.90758.2008 [Full Text] [PDF]  

Denis O'Donnell and Katherine Webb

Last Word on Point:Counterpoint: The major limitation to exercise performance in COPD is 1) inadequate energy supply to the respiratory and locomotor muscles, 2) lower limb muscle dysfunction, 3) dynamic hyperinflation
J Appl Physiol 105: 765-765, 2008; doi:10.1152/japplphysiol.90739.2008 [Full Text] [PDF]  

POINT-COUNTERPOINT COMMENTS

John B. West, Peter D. Wagner, J. Alberto Neder, Giorgio L. Scano, Norman L. Jones, Spyros G. Zakynthinos, Ioannis Vogiatzis, Linda Nici, Peter M. Calverley, Harry R. Gosker, Annemie M. W. J. Schols, Paolo Palange, Darcy D. Marciniuk, and Scott J. Butcher

The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles vs. lower limb muscle dysfunction vs. dynamic hyperinflation
J Appl Physiol 105: 758-762, 2008; doi:10.1152/japplphysiol.zdg-8100.pcpcomm.2008 [Full Text] [PDF]  

VIEWPOINT

Daniel J. Green, Gerry O'Driscoll, Michael J. Joyner, and Nigel T. Cable

Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 766-768, 2008. First published January 3, 2008; doi:10.1152/japplphysiol.01028.2007 [Full Text] [PDF]  

Bill T. Ameredes and Donald W. Michielli

Commentary on Viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 769-769, 2008; doi:10.1152/japplphysiol.zdg-8066.vpcomm.2008 [Full Text] [PDF]  

Yukihito Higashi

Commentary on Viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 770-770, 2008; doi:10.1152/japplphysiol.90321.2008 [Full Text] [PDF]  

Stephan Gielen, Rainer Hambrecht, and Gerhard C. Schuler

Commentary on Viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 771-771, 2008; doi:10.1152/japplphysiol.90348.2008 [Full Text] [PDF]  

Julianne J. Reid and John A. Hawley

Commentary on Viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 772-772, 2008; doi:10.1152/japplphysiol.90362.2008 [Full Text] [PDF]  

Gary A. Iwamoto and Amanda J. Nelson

Commentary on Viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 773-773, 2008; doi:10.1152/japplphysiol.90327.2008 [Full Text] [PDF]  

Peter D. Wagner

Commentary on Viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 774-774, 2008; doi:10.1152/japplphysiol.00095.2008 [Full Text] [PDF]  

Anthony S. Leicht, Mikko P. Tulppo, and Jonathan Golledge

Commentary on Viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 775-775, 2008; doi:10.1152/japplphysiol.90329.2008 [Full Text] [PDF]  

Melanie Elliott

Commentary on Viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 776-776, 2008; doi:10.1152/japplphysiol.00160.2008 [Full Text] [PDF]  

Jill N. Barnes and Hirofumi Tanaka

Commentary on Viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 777-777, 2008; doi:10.1152/japplphysiol.00179.2008 [Full Text] [PDF]  

Beth Parker and David Proctor

Commentary on Viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
J Appl Physiol 105: 778-778, 2008; doi:10.1152/japplphysiol.00141.2008 [Full Text] [PDF]  

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